癫痫发病机制研究的进展与脑损伤机制  

Research progress on the mechanism of epilepsy and brain damage mechanism

作　　者：张赟[1] 郑辑英[1] 李光来[1] 李东芳[1] 薛国芳[1] 

机构地区：[1]山西医科大学第二临床医院神经内科,太原030000

出　　处：《中华临床医师杂志（电子版）》2016年第8期116-119,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：癫痫是一种慢性疾病,是由于大脑神经元突发性异常放电,导致大脑功能出现短暂的障碍。癫痫的发病机制非常复杂,其主要与离子通道和遗传、神经递质、细胞因子及免疫、神经胶质细胞等关系密切,癫痫发作通常是由于中枢神经系统兴奋与抑制间的不平衡所致。本文就癫痫发病机制的有关研究的进展进行总结,从理论上为癫痫的预防、诊断与治疗提供依据。Epilepsy is a chronic disease of the brain caused by the abnormal discharge of neurons in the brain. The pathogenesis of epilepsy is very complex, which is closely related to the ion channels and genetics, neurotransmitters, cytokines, immune and glial cells. The imbalance between excitation and inhibition of the central nervous system leads to epileptic seizures. In this paper, we summarized the research progress on the mechanism of epilepsy, and provided evidence for the prevention, diagnosis and treatment of epilepsy.

关 键 词：癫痫 遗传 脑损伤 神经递质 发病机制 综述 

分 类 号：R742.1[医药卫生—神经病学与精神病学]