Correlation between the transdermal characteristics of pseudoephedrine and amygdalin in majiepingchuan in vitro  

作　　者：Kong Hui Qu Huihua Qu Baoping Zeng Wenhao Zhao Yan Wang Xueqian Wang Qingguo 

机构地区：[1]School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China [2]Center of Scientific Experiment, Beijing University of Chinese Medicine, Beijing 100029, China [3]School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China

出　　处：《Journal of Traditional Chinese Medicine》2016年第2期238-242,共5页中医杂志（英文版）

基　　金：Supported by the Science and Technology Major Projects for Major New Drugs(Research on innovation of Majiepingchuan effective components cataplasm of transdermal drug delivery system),No.2012ZX09103201-007

摘　　要：OBJECTIVE: To analyze the transdermal profile of pseudoephedrine and amygdalin in the Traditional Chinese Medicine majiepingchuan in rat skin and to reveal their interaction.METHODS: A Franz diffusion cell was used in vitro to evaluate the transdermal parameters of cumulative transdermal flux(Q_(tot)), cumulative transmission(T_(tot)), and mean penetration rate(Kp) of pseudoephedrine and amygdalin in majiepingchuan. Linear regression analyses of Q_(tot)over time of pseudoephedrine vs amygdalin and their ratios was adopted for correlation evaluation.RESULTS: At 1, 2, 4, 6, and 8 h, the Q_(tot),T_(tot)and Kp of pseudoephedrine showed a good correlation with that of amygdalin.CONCLUSION: There was a small difference in theratios of Q_(tot), T_(tot)and Kp between pseudoephedrine and amygdalin, and a correlation between them.OBJECTIVE： To analyze the transdermal profile of pseudoephedrine and amygdalin in the Traditional Chinese Medicine majiepingchuan in rat skin and to reveal their interaction.METHODS： A Franz diffusion cell was used in vitro to evaluate the transdermal parameters of cumulative transdermal flux（Q_（tot））, cumulative transmission（T_（tot））, and mean penetration rate（Kp） of pseudoephedrine and amygdalin in majiepingchuan. Linear regression analyses of Q_（tot）over time of pseudoephedrine vs amygdalin and their ratios was adopted for correlation evaluation.RESULTS： At 1, 2, 4, 6, and 8 h, the Q_（tot）,T_（tot）and Kp of pseudoephedrine showed a good correlation with that of amygdalin.CONCLUSION： There was a small difference in theratios of Q_（tot）, T_（tot）and Kp between pseudoephedrine and amygdalin, and a correlation between them.

关 键 词：PSEUDOEPHEDRINE AMYGDALIN Ma jiepingchuan Transdermal flux CORRELATION 

分 类 号：R285.5[医药卫生—中药学]