特纳综合征患者肝功能异常的高发生率及其影响因素  

High incidence of abnormal liver function and the affecting factors in patients with Turner syndrome

作　　者：李光玲[1] 阳洪波[2] 陈适[2] 朱惠娟[2] 龚凤英[2] 吕翠君 马莹莹[1,2] 潘慧[2] 

机构地区：[1]河北北方学院研究生院,河北张家口075000 [2]中国医学科学院北京协和医院内分泌科,北京100730

出　　处：《基础医学与临床》2016年第5期698-701,共4页Basic and Clinical Medicine

摘　　要：目的探讨特纳综合征(TS)患者肝功能异常的发生率及其影响因素。方法 2010年3月至2015年7月就诊于北京协和医院内分泌科矮小门诊的TS患者44例,年龄(13.6±5.0)岁;120例行健康体检的女童为正常对照,年龄(13.2±0.7)岁。全部测量身高、体质量,检测丙氨酸氨基转氨酶(ALT)、总胆红素(TBil)等肝功能指标,44例TS患者均行染色体核型分析。结果 TS患者肝功能异常的发生率为18.2%,主要表现为ALT升高,对照组肝功能异常的发生率为3.3%。TS患者ALT正常组和异常组在年龄、BMI、核型方面未见显著性差异。结论肝功能异常在TS患者中发生率高,建议定期检查肝功能。矮小伴不明原因肝功能异常的女性需注意筛查特纳综合征。Objective To investigate the incidence of abnormal liver function and the affecting factors in Turner syndrome （TS）. Methods Forty-four TS patients aged 13.6 ± 5.0 years old were recruited from the Department of Endocrinology, Peking Union Medical College Hospital during March 2010 to July 2015. And 120 girls aged 13.2 ± 0.7 years old were selected as normal controls. Height, weight and liver function tests including alanine transaminase （ALT） and total bilirubin were measured in all 164 participants. All 44 TS patients were confirmed with chromosome karyotypes. Results The incidence of abnormal liver function in TS patients was 18. 2%, mainly manifested as ALT elevation, while the incidence of abnormal liver function in control group was 3.3%. There were no significant differences in age, BMI and karyotypes among TS patients with or without ALT abnormality. Conclusions The incidence of abnormal liver function is higher in TS patients. Regular liver function tests should be performed in these patients. The diagnosis of TS should be considered when abnormal liver function is noted in female patients with short stature.

关 键 词：特纳综合征 肝功能 年龄 体质量指数 染色体核型 

分 类 号：R711.1[医药卫生—妇产科学]