在体大鼠脑部核团的微电极记录偶联行为学康复实验模型方法的建立  

Establishment of A Model in Rat Brain Nuclei Microelectrode Recording Coupled Behavioristics for Rehabilitation Experiment

作　　者：张晟豪 李楠[1] 葛顺楠[1] 李洋[1] 武松燕 王学廉[1] 刘朝晖[2] 

机构地区：[1]第四军医大学唐都医院神经外科,陕西西安市710038 [2]第四军医大学唐都医院康复医学科,陕西西安市710038

出　　处：《中国康复理论与实践》2016年第4期399-403,共5页Chinese Journal of Rehabilitation Theory and Practice

基　　金：国家自然科学基金青年科学基金项目(No.81301179;No.81401104)

摘　　要：目的建立在体大鼠脑部核团的微电极记录及行为学偶联模型。方法将大鼠背部留置管连接固定装置改进后置于大鼠背部皮下,为大鼠的相关脑部核团埋置阵列微丝电极,将神经电生理采集系统与自身给药行为学系统进行信号对接,通过自身给药训练使大鼠成瘾,在大鼠成瘾的不同状态下进行相关脑部核团的电生理信号记录。结果与结论经过改进后的留置管连接固定装置有较好的性能,脱管漏管的现象大幅度降低,自身给药系统与电生理采集系统对接后信号传输稳定,实现了大鼠脑部相关核团在自身给药行为发生过程中的神经电生理信号的同步采集。Objective To establish a coupled model combining the rat brain nuclei microelectrode recordings and the behavioristics for rehabilitation experiment. Methods The modified indwelling tube connection fixed device was put inside the rats＇ back, and the microprobes were implanted into related neural nucleus. A signal connection was made between self-administration system and electrophysiological data acquisition system. The rat was addicted after training by self-administration system. The related cerebral nucleus electrophysiological signals were recorded in different states of addiction. Results and Conclusion The modified indwelling tube connection fixed device has a better quality for reducing the phenomenon of leak. The signal was well in the combination of two different systems. The signals for the rat＇s action and neural electrical were recorded in the same time.

关 键 词：微电极记录 自身给药 脑功能 康复 神经生理 

分 类 号：R749.6[医药卫生—神经病学与精神病学]