RDW联合mGPS评分对原发性肝癌诊断及预后意义  

Diagnostic and prognostic value of RDW in combination with mGPS in primary hepatocellular carcinoma

作　　者：谢荃沁 陈陆俊[1] 蒋敬庭[1] 吴昌平[1] 

机构地区：[1]苏州大学附属第三医院肿瘤中心/江苏省肿瘤免疫治疗工程技术研究中心,常州213003

出　　处：《中国医药生物技术》2016年第2期116-122,共7页Chinese Medicinal Biotechnology

基　　金：国家科技支撑计划(2015BAI12B12);国家自然科学基金(31570877;31570908;81171653);国家自然科学基金海外及港澳学者合作研究基金(31428005);江苏省条件建设与民生科技专项资金(BL2014034)

摘　　要：目的探讨RDW联合mG PS评分对原发性肝癌诊断及预后意义。方法收集苏州大学附属第三医院原发性肝癌患者术前血样本147例、肝良性对照组182例、健康体检者95例,Logistic回归模型建立肝癌诊断模型,建立RDW联合mG PS对肝癌预后评估模型,Cox比例风险模型分析肝癌患者预后影响因素。结果 RDW、mG PS、AFP和CEA在肝癌、肝良性疾病和健康体检者中水平差异均有统计学意义(P<0.05)。RDW与mG PS联合对肝癌预后有较高预测价值(P=0.0005,HR=2.418)。mG PS为肝癌患者独立预后因素(P=0.022)。结论 RDW与mG PS联合在肝癌预后评估中具有较高应用价值。Objective To investigate the diagnostic and prognostic value of RDW in combination with mG PS in primary hepatocellular carcinoma. Methods Samples from 147 preoperative hepatocellular carcinoma, 182 benign liver diseases and 95 healthy individuals were collected. The hepatocellular carcinoma diagnostic model with RDW and m GPS was established by logistic regression model. The prognostic model was established as well. Cox proportion hazard model was used to analyze the prognostic factors of hepatocellular carcinoma. Results The levels of RDW, mG PS, AFP and CEA were discrepant in different patient group and control group（P〈0.05）. RDW in combination with mG PS had preferable prognostic value of hepatocellular carcinoma（P = 0.0005, HR = 2.418）. mG PS was an independent prognostic factor of the tumor. Conclusion The levels of serum enzyme have important value in the diagnosis and prognosis of primary hepatocellular carcinoma.

关 键 词：原发性肝癌 红细胞分布宽度 格拉斯哥预后评分 

分 类 号：R735.7[医药卫生—肿瘤]