重复经颅磁刺激治疗顽固性失眠的临床观察  

Clinical observation of repetitive transcranial magnetic stimulation in the treatment of intractable insomnia

作　　者：刘彩兴[1] 段妮[1] 张永东[1] 王立涛[1] 

机构地区：[1]青岛市精神卫生中心,青岛266034

出　　处：《国际精神病学杂志》2016年第2期263-265,共3页Journal Of International Psychiatry

摘　　要：目的探讨重复经颅磁刺激(repetitive transcranial magnetic stimulation,r TMS)治疗顽固性失眠症的临床疗效。方法将60例顽固性失眠患者,随机分为r TMS组和对照组各30例,r TMS组采用r TMS+苯二氮艹卓类药物治疗,对照组采用伪r TMS+苯二氮艹卓类药物治疗,2组患者均刺激1次/天,20min/次,连续4周。采用匹兹堡睡眠质量指数问卷、多导睡眠监测睡眠潜伏期、觉醒次数及睡眠觉醒时间评定疗效,比较两组治疗前、后临床疗效。结果 r TMS组患者治疗后匹兹堡睡眠质量指数明显低于治疗前及对照组(P<0.01);多导睡眠监测睡眠潜伏期、觉醒次数及觉醒时间较治疗前及对照组均明显减少(P<0.01)。结论 r TMS可显著缩短顽固性失眠患者的睡眠潜伏期、减少觉醒次数及觉醒时间,治疗顽固性失眠疗效可靠。Objective To investigate the effect of repetitive transcranial magnetic stimulation （ rTMS ） on intractable insomnia. Methods Sixty patients with intractable insomnia were randomly divided into rTMS group and control group, with thirty patients in each group. Patients in the rTMS group were treated with rTMS plus oral administration of benzodiazepines drugs, while patients in the control group received sham rTMS plus oral administration of benzodi- azepines drugs, for twenty minutes each time, once a day, totally for four weeks. The Pittsburgh sleep quality index questionnaire, sleep latency, number of awakening and awakening time on polysomnography were evaluated and compared the clinical efficacy before and after four weeks treatment between two groups. Results Pittsburgh sleep quality index was significantly lower, and the sleep latency, number of awakening and awakening time on polysomnography were significantly shorter after rTMS treatment than those before treatment and those in the control group （ P〈 0.01 ） . Conclusion rTMS can significantly shorten the sleep latency time, number of awakening and awakening time in the patients with intractable insomnia. It is reliable and effective for rTMS to treat intractable insomnia.

关 键 词：重复经颅磁刺激 顽固性失眠 苯二氮类药物 

分 类 号：R749.4[医药卫生—神经病学与精神病学]