氨磺必利与奥氮平治疗精神分裂症患者安全性比较  

Compare safety of amisulpride and olanzapine in the treatment of first-episode schizophrenia

作　　者：程万良[1] 朱文礼[1] 王伟[1] 王继轩 储贝贝 杨永春[1] 

机构地区：[1]芜湖市第四人民医院精神科,芜湖241000

出　　处：《国际精神病学杂志》2016年第2期279-281,共3页Journal Of International Psychiatry

基　　金：芜湖市科技惠民计划基金(项目编号:2015zd15)

摘　　要：目的比较氨磺必利与奥氮平治疗首发精神分裂症的安全性。方法对80例使用氨磺必利或奥氮平的精神分裂症患者病案资料回顾性调查分析，统计一般人口学资料、副反应、精神症状测评、实验室检查结果。结果全部80例病例中，氨磺必利组（amisulpride group，AG）性激素异常25例，奥氮平组（olanzapine group，OG）18例，差异有统计学意义（X2=4．220，P=0．40）。进一步研究发现AG组在血清泌乳素水平高于OG组[（63．12±38．74）ng／mL；（37．84±36．50）ng／mL]；差异有统计学意义（t=-3．003，P=0．004）。AG组与OG组在一般人口学资料、副反应、精神症状测评等方面差异无统计学意义。结论氨磺必利对治疗首发精神分裂症安全性与奥氮平相当，需注意氨磺必利对精神分裂症患者内分泌的影响。Objective To compare the different of safety in the treatment of first-episode schizophrenia between amisulpride and olanzapine. Methods A retrospective study was conducted 80 cases with first-episode schizophrenia treatment of amisulpride or olanzapine on the general demographic data, side reaction, evaluation of psychiatric symptoms and laboratory examination. Results All of 80 cases, The number of abnormal sex hormones was 25 case in amisulpride group, and was 18 case in olanzapine group. The difference between two groups have statistically significant （ X2=4.220, P=0.40） . Further studies conclusively showed amisulpride group had higher level of serum PRL than olanzapine group [ （ 63.12 ± 38.74 ） ng/ml; （ 37.84 ± 36.50 ） ng/ml]（ t=-3.003, P=0.004）. The difference of the general demographic data, side reaction, evaluation of psychiatric symptoms between misulpride group and olanzapine group were not significant （P 〉 0.05 ）. Conclusion The safety of amisulpride on first-episode schizophrenia is equivalent with olanzapine. We should pay attention to the influence of endocrine of the amisulpride therapy schizophrenia patients.

关 键 词：氨磺必利 奥氮平 精神分裂症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]