鱼油对ARDS患者预后影响的Meta分析  

Effects of fish oil on patients with acute respiratory distress syndrome： a meta-analysis

作　　者：李洋[1] 黄亮[1] 曹春水[1] 熊华威[1] 占钻[1] 刘勇[1] 刘坚[1] 

机构地区：[1]南昌大学第一附属医院急诊科,330000

出　　处：《国际呼吸杂志》2016年第8期593-597,共5页International Journal of Respiration

基　　金：国家临床重点专科建设项目（2013544）

摘　　要：目的评价鱼油对ARDS患者预后的影响。方法计算机及手工检索PubMed、Embase、Cochrane图书馆临床随机对照试验资料库、Highwire、中国生物医学文献数据库、中国学术期刊全文数据库（CNKI）、万方数据库，并在互联网检索正在进行的试验：Current Controlled Trial（www．controlled—trials．com）和美国国立卫生研究院临床试验数据库（www．clinicaltrials．gov）。按Cochrane系统评价的方法，选择试验、评价质量，使用Review Manager 5．2软件进行Meta分析。结果共纳入7项随机对照临床试验，包括994例研究对象。与非鱼油添加组相比：鱼油未能降低ARDS患者28d病死率（RR一0．81，95％（7／：0．56～1．18，P=0．27）；鱼油未能减少ARDS患者28d机械通气时间（WMD=-2．06，95％CI：-4．81-0．70，P=0．14）；鱼油缩短ARDS患者28d内ICU住院天数，且差异具有统计学意义（WMD=-2．47，95％CI：-4．33～～0．60，P=0．009）。结论对于ARDS患者，鱼油的摄入并不能降低病死率及缩短机械通气时间，但有助于减少ICU住院时间。Objective To evaluate the contribution of fish oil in patients with acute respiratory distress syndrome （ARDS）. Methods The PubMed, Embase, Coehrane Clinical Trials Register, Highwire, CBM, CNKI, WanFang databases and Current Controlled Trial （www. controlled-trials, corn）, the U. S. National Institute of Health Clinical Trials（www. clinicaltrials, gov） databases were searched. All related data were extracted. Meta-analysis was conducted using the statistical software Review Manager 5.2 on the basis of strict quality evaluation, the methods recommended by the Cochrane Collaboration. Results Seven randomized controlled studies （ n = 994） were included in this meta-analysis. Compared with the non-fish oil group, 28-day mortality was not decreased in the fish oil group （ RR ：0.81,95% CI ： 0.56-1.18, P =0.27）, the time of mechanical ventilation was not decreased in the fish oil group （WMD= -2.06,95% CI ：-4.81-0.70, P = 0.14）, ICU stay time was significantly lower in the fish oil group （WMD=-2.47,95% CI ：-4.33--0.60, P =0.009）.Conclusions For patients withARDS, fishoilis non-beneficial in improving the survival and decreasing the time of mechanical ventiation, but can reduce ICU stay time.

关 键 词：鱼油 急性呼吸窘迫综合征 预后 META分析 

分 类 号：R563.8[医药卫生—呼吸系统]