肿瘤靶向型pH敏感多肽类药物递送系统研究进展  

Advances of tumor targeting peptides drug delivery system with pH-sensitive activities

作　　者：马银云 李莉[1] 黄海凤[1] 缑三虎 倪京满[1] 

机构地区：[1]兰州大学,药学院,药剂学研究所,甘肃兰州730000

出　　处：《药学学报》2016年第5期717-724,共8页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81273440)

摘　　要：pH敏感性多肽类药物递送系统,以肿瘤组织酸性的细胞外环境为靶点,具有肿瘤特异性高、细胞毒性低,且能显著提高传统抗癌药物的活性等优点,近年来受到了广泛的关注。本文总结了5种类型靶向作用于肿瘤细胞的pH敏感性多肽类药物递送系统的研究进展,对今后肿瘤靶向型药物的设计和应用有重要意义。The pH-sensitive peptides drug delivery systems,which target to acidic extracellular environment of tumor tissue,have many advantages in drug delivery.They exhibit a high specificity to tumor and low cytotoxicity,which significantly increase the efficacy of traditional anti-cancer drugs.In recent years the systems have received a great attention.The pH-sensitive peptides drug delivery systems can be divided into five types according to the difference in pH-responsive mechanism,type of peptides and carrier materials.This paper summarizes the recent progresses in the field with a focus on the five types of pH-sensitive peptides in drug delivery systems.This may provide a guideline to design and application of tumor targeting drugs.

关 键 词：PH敏感 多肽 肿瘤靶向 药物递送系统 

分 类 号：R943[医药卫生—药剂学]