肠道微环境与溃疡性结肠炎  

Intestinal micro-ecology and ulcerative colitis

作　　者：周正华[1] 

机构地区：[1]天津中医药大学第一附属医院脾胃科,天津市300381

出　　处：《世界华人消化杂志》2016年第11期1695-1700,共6页World Chinese Journal of Digestology

摘　　要：溃疡性结肠炎(ulcerative colitis,UC),是炎症性肠病(inflammatory bowel disease,IBD)中的一个亚型,其病因及发病机制尚未明确,主要表现为结肠黏膜病变,多以溃疡为主,病变部位多发生在直肠和乙状结肠,甚则累及整个结肠.近年来,随着肠道微生物学理论研究的不断突破,其在UC的诊断和治疗方面涌现出新的热点,包括肠道菌群的分类及其对肠道黏膜和肠道免疫的影响等,这可能会突破UC原有的诊疗方法,发展为研究UC诊治的新方向,本文就肠道微环境与UC的内在机制作一综述.Ulcerative colitis（UC） is a subtype of inflammatory bowel disease, and its etiology and pathogenesis are not yet clear. UC often shows lesions（mainly ulcer） in the mucosa of the colon, rectum and sigmoid colon, eveninvolving the entire colon. In recent years,with the constant breakthroughs in theoretical research of intestinal microbiology, its use in the diagnosis and treatment of UC has emerged as a new hot spot. Clarification of the classification of intestinal flora and its effect on the intestinal mucosa and intestinal immunity may provide a new avenue for treatment of UC. In this paper, we will review the relationship between intestinal microenvironment and UC.

关 键 词：肠道微环境 溃疡性结肠炎 肠道黏膜屏障 肠道免疫 

分 类 号：R574.62[医药卫生—消化系统]