结构修饰的烟酰胺类杀菌剂杀菌性能研究  

Study of Antimicrobial Activities of New Nicotinamide-quaternary Ammonium Salts

作　　者：李银涛[1] 贾瑞虹[1] 卫星星[1] 贾钰霞[1] 

机构地区：[1]长治医学院药学系,046000

出　　处：《长治医学院学报》2016年第2期89-91,共3页Journal of Changzhi Medical College

基　　金：国家大学生创新性实验计划项目(201210117002)

摘　　要：目的:探讨在烟酰胺分子中引入长链溴代烷得到修饰化合物的杀菌活性。方法:采用琼脂稀释法对其杀菌活性进行测试。结果:结构修饰的烟酰胺具有比洁尔灭较强的杀菌活性,尤其对大肠杆菌显示出比洁尔灭更好的效果,抗菌能力可达到98.52%。结论:修饰后的烟酰胺对大肠杆菌、枯草杆菌、金黄色葡萄球菌和白色念珠菌都具有不同程度的杀灭作用。Objective：To explore the transformation of nicotinamide structure,introducing long chain alkyl bromide in the molecular structure,and test the modified compound bactericidal activity.Methods：Agar dilution method were used to test its bactericidal activity.Results：The structural modification of nicotinamide has strong bactericidal activity than Bromo Geramine,especially of Escherichia coli showed better effect,and the antibacterial ability 98.52% can be achieved.Conclusion：Modified nicotinamide has different degree of killing effect on E.Coli,B.Subtilis,S.Aureu and C.Albicans.

关 键 词：长链溴代烷 烟酰胺 结构修饰 杀菌活性 

分 类 号：R914[医药卫生—药物化学]