上皮间质转化在宫颈癌侵袭和转移中的作用研究  

Study in the effect of epithelial-mesenchymal transition in the invasion and metastasis of cervical cancer

作　　者：巴彩霞[1] 郭佳[2] 白雪峰[2] 

机构地区：[1]内蒙古自治区包头市肿瘤医院妇瘤科,内蒙古包头014030 [2]内蒙古自治区包头市肿瘤医院病理科,内蒙古包头014030

出　　处：《中国现代医生》2016年第9期5-8,共4页China Modern Doctor

摘　　要：目的探讨上皮间质转化(epithelial-mesenchymal transition,EMT)对宫颈癌侵袭和转移的影响。方法对33例宫颈浸润癌组织和23例宫颈原位癌组织(对照组)采用免疫组化方法进行EMT标志物的检测。结果 (1)免疫组化检测显示56例宫颈癌组织中,发生浸润及淋巴结转移后,E-cadherin/β-catenin复合物的表达显著低于原位癌组织(P<0.05),而Vimentin的表达显著高于原位癌组织(P<0.05)。(2)浸润性宫颈癌组织中Fibronectin及Ncadherin表达与组织学分级密切相关。(3)FN的表达与癌组织的浸润深度相关。结论宫颈癌的侵袭转移过程中存在着EMT现象,可以为宫颈癌的靶向治疗提供理论依据。Objective To investigate the effect of EMT on the invasion and metastasis of cervical cancer. Methods Immunohistochemistry was use to detectded the expression of markers of EMT in 33 cases of invasive cervical cancer and23 cases of cervical carcinoma in situ（control group）. Results（1）Expression of E-cadherin/β-catenin in invasive carcinoma and lymph node metastasis group was lower than carcinoma in situ（P〈0.05）, and expression of Vimentin in invasive carcinoma and lymph node metastasis group was higher than carcinoma in situ（P〈0.05）.（2）The expression of FN and N-cadherin had relations with histological grade in Invasive cervical cancer.（3）The expression of FN had relations with invasive depth of carcinoma. Conclusion Invasion and metastasis of cervical cancer exists phenomenon of EMT,which may provide a theoretic basis for the targeted treatment of cervical cancer.

关 键 词：EMT 宫颈癌 转移 免疫组化 

分 类 号：R737.3[医药卫生—肿瘤]