miR-137基因多态性与中国南方人群精神分裂症的关联性研究  

Association of miRNA-137 polymorphism with schizophrenia in a southern Chinese Han population

作　　者：罗旭东 符家武 梁爱萍 殷静雯 

机构地区：[1]广东医科大学附属医院精神心理科,广东湛江524001 [2]广东医科大学附属医院神经内科,广东湛江524001 [3]广东医科大学附属医院血液透析中心,广东湛江524001

出　　处：《重庆医学》2016年第13期1733-1735,1739,共4页Chongqing medicine

基　　金：国家自然科学基金资助项目(31171219)

摘　　要：目的采用中国南方汉族人群样本对miR-137基因多态性与精神分裂症的相关性进行研究。方法收集944例精神分裂症患者（精神分裂症组）及938例健康对照者（对照组）外周血液，采用SnaPshot技术对rs1625579位点进行基因分型，比较该位点等位基因频率分布在精神分裂症组和对照组，以及在精神分裂症患者临床变量分组中的差异。结果在精神分裂症组和对照组中基因型分布差异有统计学意义（x2=4．426，P=0．035），等位基因分布差异有统计学意义（x2=4．813，P=0．028）。按性别分组后，女性精神分裂患者和对照组之间基因型分布差异有统计学意义（x2=3．928，P=0．047），等位基因分布差异有统计学意义（x2=3．957，P=0．047）。结论研究结果证实了miR-137基因多态性与精神分裂症的相关性，同时发现了miR-137在精神分裂症发病调控过程中的性别特异性。Objective To assay the association between miR-137 gene polymorphism and schizophrenia in a southern Chinese Han population. Methods We genotyped 944 schizophrenic patients and 938 controls for the risk single nucleotide polymorphism （SNP） rs1625579 by the SnaPshot technique and compared the clinical profiles and neurocognitive functions of different genotypes. Results Both the genotype and allele distributions of the rs1625579 SNP were significantly different between patients and controls （X2 = 4. 426, P = 0. 035 ; X2 = 4.813, P = 0. 028）. Gender-stratified analysis revealed the significant difference in genotype and allele distributions in female patients（X2= 3. 928,P=0. 047;X2 = 3. 957, P= 0. 047）. Conclusion The results of our study verifies that miR-137 gene polymorphism is associated with schizophrenia. It is discovered that miR-137 has the gender specificity in the regulation process of schizophrenia pathogenesis.

关 键 词：多态现象 遗传 基因 精神分裂症 miR-137 rs1625579多态性 汉族 

分 类 号：R749.3[医药卫生—神经病学与精神病学]