扶正抑癌方对结肠癌根治术后患者血清IGF-1、EGF、TK1、CRP、CA199及CD4^+淋巴细胞亚群水平的影响  

Effect of Fuzhengyiai recipe on serum IGF-1,EGF,TK1,CRP,CA199 and CD4^+ lymphocyte subsets in patients after traditional radical resection of colon cancer

作　　者：殷华芳[1] 王琼[1] 孙霞[1] 袁明[1] 吴丹[1] 

机构地区：[1]江阴市人民医院肿瘤内科,江苏江阴214400

出　　处：《海南医学院学报》2016年第12期1236-1239,共4页Journal of Hainan Medical University

基　　金：江苏省科技厅临床医学专项(BL2015198)~~

摘　　要：目的:探讨扶正抑癌方对结肠癌根治术后患者血清胰岛素样生长因子1(insulin-like growth factor-1,IGF-1)、表皮生长因子(epidermal growth factor,EGF)、细胞质胸苷激酶1(thymidine kinase-1,TK1)、C反应蛋白(C reaction protein,CRP)、糖类抗原199(carbohydrate antigen 199,CA199)及CD4^+淋巴细胞亚群水平的影响。方法:选择2013年1月~2015年12月江阴市人民医院确诊的120例结肠癌根治术后患者,随机分为实验组(n=60)和对照组(n=60)。对照组患者予XELOX方案化疗,实验组患者在对照组的基础上给予扶正抑癌方,21d为1个周期,两组患者均接受治疗3周期,检测并比较两组患者治疗前后血清IGF-1、EGF、TK1、CRP、CA199水平及外周血CD3^+、CD4^+、CD8^+及自然杀伤(NK)细胞所占的比值。结果:治疗前,两组患者血清IGF-1、EGF、TK1、CRP、CA199水平及外周血NK、CD3^+、CD4^+、CD8^+细胞所占比值水平比较差异无统计学意义(P>0.05);治疗后,两组患者血清IGF-1、EGF、TK1、CRP及CA199水平均明显低于治疗前,同时实验组患者上述各指标均明显低于对照组,差异具有统计学意义(P<0.05);治疗后,对照组患者外周血NK、CD3^+、CD4^+及CD8^+细胞所占比值明显低于治疗前,同时实验组各免疫功能指标明显高于对照组,差异具有统计学意义(P<0.05)。结论:扶正抑癌方能明显降低结肠癌根治术患者术后血清IGF-1、EGF、TK1、CRP及CA19-9水平,提高CD4^+等淋巴细胞亚群水平,提高机体免疫功能,值得在临床上推广应用。Objective：To study the effect of Fuzhengyiai recipe on serum IGF-1、EGF、TK1、CRP、CA199and CD4^＋lymphocyte subsets in patients after traditional radical resection of colon cancer.Methods：A total of 120 patients with colon cancer in our hospital from January 2013 to December 2015 were enrolled in this study.The subjects were divided into control group（n=60）and experiment group（n=60）randomly.The control group were treated with capecitabine and oxaliplatin on the basis of the traditional radical resection of colon cancer,the experiment group were treated with Fuzhengyiai recipe on the basis of the control group.21 days for a period of treatment and the two groups were treated for 3periods.The serum IGF-1,EGF,TK1,CRP,CA19-9level and peripheral blood CD3^＋,CD4^＋,CD8^＋and NK cells of the two groups before and after treatment were compared.Results：There were no significantly differences of the serum IGF-1,EGF,TK1,CRP,CA199 level and peripheral blood CD3^＋,CD4^＋,CD8^＋and NK cells of the two groups before treatment（P〈0.05）.The serum IGF-1,EGF,TK1,CRP and CA19-9level of the two groups after treatment were significantly lower than before treatment（P〈0.05）,and that of experiment were significantly lower than control group（P〈0.05）.The peripheral blood CD3^＋,CD4^＋,CD8^＋and NK cells of the control group were significantly lower than before treatment（P〈0.05）,and that of experiment were significantly higher than control group（P〈0.05）.Conclusion：Fuzhengyiai recipe can significantly reduce the serum IGF-1,EGF,TK1,CRP and CA199 level of the patients after traditional radical resection of colon cancer,improve peripheral blood CD3^＋,CD4^＋,CD8^＋and NK level,strengthen the immune function,and it is worthy clinical application.

关 键 词：结肠癌根治术 扶正抑癌方 胰岛素样生长因子1 表皮生长因子 细胞质胸苷激酶1 C反应蛋白 糖类抗原199 CD4^+淋巴细胞亚群 

分 类 号：R735.35[医药卫生—肿瘤]