TACE联合放射性粒子组织间放疗对原发性肝癌患者恶性生物学指标的影响  

Influence of TACE combined with radioactive seed radiotherapy on primary liver cancer patients' malignant biological indicators

作　　者：刘尧[1] 王宇[2] 雷光焰 闫晓红[1] 杨乔[1] 周海平[1] 耿熠[1] 

机构地区：[1]陕西省宝鸡市中心医院肿瘤内科,陕西宝鸡721008 [2]第四军医大学西京医院肿瘤中心,陕西西安710032 [3]陕西省肿瘤医院胸外科,陕西西安710061

出　　处：《海南医学院学报》2016年第12期1303-1306,共4页Journal of Hainan Medical University

基　　金：国家自然科学基金(31501153);中国博士后科学基金(2014M562552)~~

摘　　要：目的:分析TACE联合放射性粒子组织间放疗对原发性肝癌患者恶性生物学指标的影响。方法:选择在陕西省宝鸡市中心医院、西京医院和陕西省肿瘤医院接受治疗的原发性肝癌患者112例作为研究对象,根据治疗方式不同将所有入组患者分为对照组(单纯TACE治疗)63例,观察组(TACE联合放射性粒子组织间放疗)49例,比较两组患者治疗2月后血清各项恶性生物学指标水平差异。结果:观察组患者接受治疗后的血清VEGF、FGF及MMP水平显著低于对照组患者(P<0.05);血清AFPL3、GP73、Sb7-H3、AFU、CatS水平均显著低于对照组患者(P<0.05);血清ICAM-1、ESM-1及uPA水平均低于对照组患者(P<0.05)。结论:TACE联合放射性粒子组织间放疗可以有效降低原发性肝癌患者血清各项恶性生物学指标水平,减弱癌细胞恶性程度并延缓病情进展,是原发性肝癌患者的理想治疗方式。Objective：To analyze the influence of TACE combined with radioactive seed radiotherapy on primary liver cancer patients＇ malignant biological indicators.Methods：A total of 112 cases of primary liver cancer patients who received treatment in our hospital,Xijing Hospital and Tumor Hospital of Shaanxi Province were chosen as research subjects and divided into control group（TACE therapy alone）with 63 cases in it and observation group（TACE combined with radioactive seed radiotherapy）with 49 cases according to different treatment,and then the levels of malignant biological indicators after 2months of treatment were compared between two groups.Results：Serum VEGF,FGF and MMP levels of observation group after treatment were significantly lower than those of control group（P〈0.05）;serum AFP-L3,GP73,Sb7-H3,AFU and CatS levels were significantly lower than those of control group（P〈0.05）;serum ICAM-1,ESM-1and uPA levels were lower than those of control group（P〈0.05）.Conclusion：TACE combined with radioactive seed radiotherapy can effectively reduce primary liver cancer patients＇ serum malignant biological indicator levels,decrease the degree of malignancy of cancer cells and slow disease progression,and is an ideal treatment.

关 键 词：原发性肝癌 放射性粒子组织间放疗 TACE 恶性生物学指标 

分 类 号：R735.7[医药卫生—肿瘤]