谷氨酰胺对胃癌患者血清VEGF,IL-8及肿瘤标志物水平的影响  

Effect of Glutamine on the Serum Levels of VEGF, IL-8 and Tumor Markers in Patients with Gastric Cancer

作　　者：王白波 赵永福[2] 马刚[1] 黄健[1] 侯英奎 张达[1] 

机构地区：[1]广元市第一人民医院普外二科,四川广元628400 [2]大连医科大学附属二医院,辽宁大连116000

出　　处：《现代生物医学进展》2016年第12期2342-2345,共4页Progress in Modern Biomedicine

基　　金：四川省卫生厅科研项目(100077)

摘　　要：目的:探讨谷氨酰胺对胃癌术后血清VEGF、IL-8及肿瘤标志物水平影响。方法:收集我院胃癌需进行胃癌根治术患者92例,随机分为实验组和对照组。两组患者均根据自身病情进行胃癌根治术。术后第1天予250 mL生理盐水+2 mL亚甲蓝确认无反流后,对照组予以5%葡萄糖溶液500 mL泵入,第2天予能全力500 mL,第3天开始予以能全力1500 mL泵入;实验组在对照组基础上加用谷氨酰胺。两组均术前及术后第10天进行血清VEGF、IL-8及肿瘤标志物CEA、CA72-4、CA19-9水平检测。并于术前及术后1个月进行疼痛评估和生存质量评分。结果:1术后第10天两组患者血清VEGF、IL-8及肿瘤标志物CEA、CA72-4、CA19-9水平均下降,与对照组比较,实验组下降均更明显,差异有统计学意义(P<0.05);2术后1个月两组患者VRS疼痛等级均下降,生存质量WHOQOL评分均上升,与对照组比较,实验组无疼痛人数明显增多、生存质量评分更高,差异有统计学意义(P<0.05)。结论:谷氨酰胺可更显著改善胃癌术后患者血清VEGF、IL-8及肿瘤标志物水平,对提高患者机体免疫力、改善营养状态、提高患者生活质量有重要意义。Objective： To investigate the effect of glutamine on the serum levels of VEGF, IL-8 and tumor markers in postoperative gastric cancer patients. Methods： 92 patients undergoing radical gastroectomy for gastric cancer from our hospital were selected and randomly divided into the control group and the experiment group. The patients were performed according to their own conditions for gastric cancer radical operation. After first day of operation, the 250 m L normal saline ＋2 m L methylene blue was confirmed to have no reflux, and then the patients in control group were treated with 500 m L 5 % glucose solution, and pumped into1500 m L nutrison liquid on 2nd day and 1500 m L nutrison liquid on 3rd day. On the basis of the control group, the experimental group was treated with glutamine. The serum levels of VEGF, CEA and tumor markers IL-8, CA72-4 and CA19-9 were tested and compared on the tenth day after surgery. The pain assessment and quality of life score were compared in preoperative and postoperative 1 month. Results：Compared with before treatment, the serum levels of VEGF, CEA and tumor markers IL-8, CA72-4 and CA19-9 were lower in the tenth day after surgery（P〈0.05）, and the decrease of these indexes in the experiment group were more obviously（P〈0.05）. Compared with before treatment, the VRS pain rating were lower in 1 month after operation（P〈0.05）, and the WHOQOL score were higher（P〈0.05）,and the experiment group were superior to the control group（P〈0.05）. Conclusions： Glutamine can significantly improve serum VEGF,IL-8 and tumor markers in patients with gastric cancer after operation, which is important to improve the body immunity, improve the nutritional status and the life quality of patients.

关 键 词：谷氨酰胺 胃癌术后 VEGF IL-8 肿瘤标志物 

分 类 号：R735.2[医药卫生—肿瘤]