35岁以下年轻乳腺癌患者的临床特征及预后因素分析  

Clinical Characteristics and Prognostic Factors of Breast Carcinoma in Women Aged 35 Years or Younger

作　　者：张军[1] 张永庆[2] 王昌亮[2] 王礼泉[2] 林明臻[2] 贾谊君[2] 王会东[2] 

机构地区：[1]潍坊医学院,山东潍坊261053 [2]潍坊市人民医院乳腺外科,山东潍坊261041

出　　处：《现代生物医学进展》2016年第12期2346-2350,共5页Progress in Modern Biomedicine

摘　　要：目的:探讨年轻乳腺癌患者的临床病理特点及影响其预后的相关因素。方法:选取潍坊市人民医院2005年11月至2011年11月收治的年龄不高于35岁的137例年轻乳腺癌患者的临床资料,其中共有116例入组,初步分析年轻乳腺癌患者的临床病理特征及对预后产生的影响。结果:116例患者中位随访时间为46.0个月。3年OS和PFS为94.6%和79.1%。单因素、多因素分析结果显示淋巴结转移情况和Ki67水平与预后的显著相关(P<0.05),淋巴结转数目、Ki67水平与预后呈负相关。结论:年轻乳腺癌患者的生物学行为、病理及预后较为特殊。淋巴结转移情况、Ki67水平是影响预后的关键因素。Objective： To analyze the clinical and pathological features and prognosis of breast cancer in women under 35 years old. Methods： The clinicopathological data from 137 patients with breast cancer treated in Weifang People＇s hospital between November2005 and November 2011 were retrospectively reviewed and 116 cases were enrolled into the group. The clinical and pathological features and prognostic factors were analyzed by statistical software. Results： The overall Median follow-up time was 46.0 months. The3-year progression-free survival rate was 94.6 % and the 3-year overall survival rate was 79.1%. Univariate and multivariate analysis showed that axillary lymph node status, high expression of Ki67 were related factors influencing the prognosis for breast cancer in women age under 35 years old. Conclusions： Breast cancer in young women has unique characteristics in biological behaviors, diagnosis,prognosis, and other factors. Lymph node metastasis and Ki67 level are the key factors influencing the prognosis of breast cancer in young women.

关 键 词：乳腺癌 年轻 临床特征 预后 

分 类 号：R737.9[医药卫生—肿瘤]