3D打印制作个性化下颌骨三维网状修复体支架数字化建模方法的研究  

Digital modeling for the individual mandibular 3D mesh scaffold based on 3D printing technology

作　　者：鄢荣曾[1] 骆丹媚 秦晓宇[3] 李润欣[1] 荣起国[2] 胡敏[1] 

机构地区：[1]解放军总医院口腔科,北京100853 [2]北京大学工学院力学与工程科学系,100871 [3]北京航空航天大学能源与动力工程学院,100191

出　　处：《中华口腔医学杂志》2016年第5期280-285,共6页Chinese Journal of Stomatology

摘　　要：目的研究修复重建下颌骨缺损的三维网状组织工程支架的理想建模方法，探讨验证3D打印制备钛支架的可行性、有效性。方法以1名成年女性志愿者三维CT数据资料作为建模素材，用Mimics15．0和Geomagicstudio12．0逆向工程软件将cT扫描数据生成下颌骨曲面模型切割分离拟缺损区域；镜像设计修复体外形作为支架的外部形态。同时采用UGNX8．5软件建立规则网状结构与修复体外形模型之间布尔运算获得满足组织工程要求的支架和应用ANSYS14．0软件设计支架内部三维网状结构，调整三维网状钛支架拓扑结构及几何参数实体建模，将计算机辅助设计技术方法建立的两种实体模型输入3D打印设备完成钛支架的制备。结果方法一应用简单实体特征布尔运算构建网状结构的设计可以有制造各种孔隙的网状支架复杂外形的能力，缺乏对网状结构（如网状单元结构参数、空间走向等）的调控；方法二网格单元映射逆向构建网状结构的设计中3种工况正中咬合牙尖交错位、前牙咬合及右侧磨牙咬合载荷作用下的应力峰值分别为73．63、70．14及90．88MPa，有限元拓扑优化使应力峰值下降10％，体积减小43％，孔隙率提高到76．32％。结论3D打印技术结合有限元拓扑优化获得理想的下颌骨三维网状修复体支架的方案是可行、有效的，为骨组织工程支架的制备提供理论依据和应用方法。Objective To investigate an ideal modeling method of designing 3D mesh scaffold substitutes based on tissue engineering to restore mandibular bone defects. By analyzing the theoretical model from titanium scaffolds fabricated by 3D printing, the feasibility and effectiveness of the proposed methodology were verified. Methods Based on the CT scanned data of a subject, the Mimics 15.0 and Geomagic studio 12.0 reverse engineering software were adopted to generate surface model of mandibular bone and the defect area was separated from the 3D model of bone. Then prosthesis was designed via mirror algorithm, in which outer shape was used as the external shape of scaffold. Unigraphics software NX 8.5 was applied on Boolean calculation of subtraction between prosthesis and regular microstructure structure and ANSYS 14.0 software was used to design the inner construction of 3D mesh scaffolds. The topological structure and the geometrical parameters of 3D mesh titanium scaffolds were adjusted according to the aim of optimized structure and maximal strength with minimal weight. The 3D mesh scaffolds solid model through two kinds of computer-aided methods was input into 3D printing equipment to fabricate titaniumscaffolds. Results Individual scaffolds were designed successfully by two modeling methods. The finite element optimization made 10% decrease of the stress peak and volume decrease of 43%, and the porosity increased to 76.32%. This modeling method was validated by 3D printing titanium scaffold to be feasible and effective, Conclusions 3D printing technology combined with finite element topology optimization to obtain the ideal mandibular 3D mesh scaffold is feasible and effective.

关 键 词：下颌骨 三维网状支架 3D打印 

分 类 号：R782.4[医药卫生—口腔医学]