加压素1a受体敲除对小鼠自发活动和学习记忆的影响  

Effects of Vasopressin V1a Receptor Knockout on Locomotive Activity,Learning and Memory in Mice

作　　者：郜伟莉 李向华[1] 李炎坤[1,2] 

机构地区：[1]湖北科技学院药学院药理学教研室,湖北咸宁437100 [2]湖北科技学院糖尿病心脑血管病变湖北省重点实验室

出　　处：《湖北科技学院学报（医学版）》2016年第2期106-107,共2页Journal of Hubei University of Science and Technology(Medical Sciences)

基　　金：湖北省自然基金面上项目(2014CFB186);湖北科技学院糖尿病专项(14zx04;ZX1206);湖北科技学院博士启动基金(BK1208);湖北科技学院校级青年科研项目(KY11092)

摘　　要：目的探讨加压素1a受体(VlaR)在小鼠自发活动和学习记忆中的作用。方法同窝野生(WT)小鼠和V1aR敲除(KO)小鼠各10只,采用旷场实验检测两组小鼠的自发活动,采用新物体认知实验检测两组小鼠的记忆能力。结果两组小鼠自发活动无明显差别(P>0.05),KO组小鼠的对新物体认知能力显著低于WT组(P<0.01)。结论 V1aR敲除不影响小鼠自发活动,但损伤小鼠记忆能力,提示V1aR在学习记忆中发挥重要作用。Objective To investigate the effects of vasopressin V1 a receptor（ V1aR） on locomotive activity,learning and memory in mice. Methods Behavioral experiments were performed in littermate wild-type（ WT） and V1 aR knockout（ KO） mice,10 mice each group. Open field test was employed to detect locomotive activity of WT and KO mice,and novel object recognition test was used to detect novel object recognition. Results Compared with WT mice,V1 aR KO mice showed normal locomotive activity（ P〉0. 05） and exhibited an impairment in novel object recognition（ P〈0. 01）. Conclusion V1 aR knockout has no effect on locomotive activity,but impairs novel object recognition of mice,suggesting that V1 aR plays an important role in learning and memory.

关 键 词：加压素1a受体 自发活动 学习记忆 

分 类 号：R-322[医药卫生]