粪菌移植联合聚乙二醇治疗顽固性功能性便秘的疗效观察  

Effect of Fecal Microbiota Transplantation Combined with Polyethylene Glycol in the Treatment of Patients with Intractable Constipation

作　　者：刘巧云[1,2] 张松[1] 曹海超 李婷宇 马玉帛 赵欣[4] 蒋铭佐 刘健[1] 惠娜[1] 王美霞[1] 聂燕[1] 吴开春[1] 聂勇战[1] 

机构地区：[1]第四军医大学西京消化病院肿瘤生物学国家重点实验室,陕西西安710032 [2]宁夏西吉县人民医院,宁夏西吉756200 [3]重庆医科大学第一临床学院,重庆400016 [4]第四军医大学唐都医院放射科,陕西西安710038

出　　处：《现代生物医学进展》2016年第11期2066-2069,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81470816);国家杰出青年科学基金项目(81225003)

摘　　要：目的:探讨粪菌移植(FMT)联合聚乙二醇治疗顽固性功能性便秘的临床疗效及对患者生活质量及心理状态的影响。方法:选择第四军医大学西京消化病院2013年11月至2015年5月门诊顽固性功能性便秘患者35例,所有患者均行FMT治疗,同时联合聚乙二醇电解质散剂,疗程4周,采用便秘患者症状评分量表(KESS)、生存质量量表(PAC-QOL)、Zung焦虑自评量表(SAS)及抑郁自评量表(SDS)观察治疗前后及随访3个月便秘患者症状、生活质量及心理状态的改变。结果:治疗后及随访3个月时,患者的临床治愈率分别为37.1%、34.3%,改善率分别为77.1%、71.4%,KESS、PAC-QOL、SAS、SDS总评分均较治疗前明显减低(P<0.05)。治疗及随访期间均未发生严重不良反应。结论:FMT联合聚乙二醇能安全、有效的改善顽固性功能性便秘患者的相关症状,提高生活质量,改善异常心理状态,值得临床推广。Objective： To investigate the clinical efficacy of fecal microbiota transplantation（FMT） combined with polyethylene glycol on intractable constipation and its effect on the quality of life and psychological states.Methods： A total of 35 patients with intractable constipation were treated with combined therapy of FMT and polyethylene glycol for 4 weeks in our department from November 2013 to May 2015.Knowles-Eccersley-Scott-Symptom（KESS） score,the patient assessment of constipation quality of life（PAC-Qo L） score,Zung selfrating anxiety scale（SAS） and selfrating depression scale（SDS） were recorded to assess the effects before and after treatment.Results： After treatment,the clinical recovery rate and improvement rate were 37.1 % and 77.1 %,which were 34.3% and 71.4 % after 3 months＇ follow-up,the KESS,PAC-Qo L,SAS and SDS scores were all significantly decreased compared with those before treatment（P〈0.05）.No serious adverse event occurred during the whole follow-up.Conclusions： Combination of Fecal microbiota transplantation and polyethylene glycol could significantly improve the quality of life and the abnormal psychological status of patients with intractable constipation.

关 键 词：粪菌移植 顽固性功能性便秘 生活质量 心理状态 

分 类 号：R574.6[医药卫生—消化系统] R442.2[医药卫生—内科学]