吲哚美辛栓剂对预防ERCP术后高淀粉酶血症及胰腺炎的效果观察  

Observation of Indomethacin Suppository for the Prevention of Hyperamylasemia and Pancreatitis after ERCP Operation

作　　者：吴佩宏 王霞[2] 杨冬英[1] 殷德荣[1] 柴小萍 李坤[3] 

机构地区：[1]汉中市人民医院消化内科,陕西汉中723000 [2]汉中市中心医院介入科,陕西汉中723000 [3]西安交通大学第一附属医院消化内科,陕西西安710061

出　　处：《现代生物医学进展》2016年第11期2151-2153,共3页Progress in Modern Biomedicine

基　　金：陕西省自然科学基金项目(2014JM4141)

摘　　要：目的:探讨吲哚美辛栓剂对预防ERCP术后高淀粉酶血症及胰腺炎的效果。方法:选取2010年10月-2015年6月收治入院的行ERCP手术的患者300例,随机分为观察组及对照组各150例,观察患者ERCP术后立即应用吲哚美辛栓剂直肠给药,对照组给予安慰剂栓剂,术后3 h,24 h检测血清淀粉酶,观察高淀粉酶血症及胰腺炎的发生情况。结果:术前两组血清淀粉酶比较差异无统计学意义(P>0.05);术后3 h,24 h两组血清淀粉酶均升高,且观察组高于对照组,差异均具有统计学意义(t=5.794、10.816,P均<0.05)。观察组高淀粉酶血症及ERCP术后胰腺炎的发生率明显低于对照组,差异均具有统计学意义(x^2=5.927;2.160,P<<0.05)。结论:直肠给药吲哚美辛栓剂可明显降低ERCP术后血清淀粉酶量,降低高淀粉酶血症及ERCP术后胰腺炎的发生率。Objective： To investigate the effect of indomethacin for the prevention of hyperamylasemia and pancreatitis after ERCP operation.Methods： a total of 300 patients with October 2010 to June 2015 were randomly divided into observation group and control group for each 150 cases.The patients in observation group were given indometacin suppositories by rectal administration,and the patients in control group were given placebo suppository.The serum amylase was detected,and the incidence hyperamylasemia and pancreatitis was observed in 3 h,24 hours after operation.Results： There was no significant difference in the serum amylase before treatment between the two groups（P〈0.05）; After treatment for 3 h and 24 h,the serum amylase was increased in the two groups,and it was higher in the observation group than that of the control group with statistical significance（t=5.794,10.816,P〈0.05）; and the incidence of hyperamylasemia and pancreatitis after ERCP in the observation group was significantly lower than that of the control group,and the difference was statistically significant（x^2=5.927,2.160,P〈0.05）.Conclusions： The rectal indomethacin suppository can significantly decrease the serum amylase level after ERCP and reduce the incidence of hyperamylasemia and PEP.

关 键 词：吲哚美辛 ERCP 高淀粉酶血症 胰腺炎 栓剂 

分 类 号：R576[医药卫生—消化系统]