艾地苯醌对血管性痴呆大鼠学习记忆的影响  

Effects of Idebenone on learning and memory impairments of vascular dementia in rats

作　　者：艾鑫[1] 庞永斌[1] 刘翠[1] 

机构地区：[1]延安大学附属医院神经外科,延安716000

出　　处：《陕西医学杂志》2016年第5期517-518,549,共3页Shaanxi Medical Journal

摘　　要：目的:研究艾地苯醌对血管性痴呆大鼠学习记忆的影响及其机制。方法:将60只SD大鼠随机分为血管性痴呆干预组、血管性痴呆对照组、假手术组。采用双侧颈总动脉结扎建立血管性痴呆大鼠模型。水迷宫实验反映艾地苯醌对血管性痴呆大鼠学习记忆的影响,并测定大鼠脑组织中乙酰胆碱酯酶、胆碱乙酰转移酶、超氧化物歧化酶和丙二醛含量。结果:血管性痴呆干预组与血管性痴呆对照组比较,Morris水迷宫实验结果显示:大鼠寻找平台的潜伏期明显缩短(P<0.05),穿越平台的次数明显增多(P<0.05);生化指标检测:大鼠脑组织乙酰胆碱酯酶和丙二醛含量显著降低(P<0.05),胆碱乙酰转移酶和超氧化物歧化酶含量显著升高(P<0.05)。结论:艾地苯醌对血管性痴呆大鼠学习记忆障碍有显著改善作用,其机制可能与其降低脑组织中氧化应激水平及增加胆碱能神经功能有关。Objective：To investigate the effect of Idebenone on learning and memory impairments of vascular dementia in rats and its possible mechanism of neuroprotection.Methods：60male SD rats were employed and randomly divided into vascular dementia intervention group（n=20）,vascular dementia group（n=20）and sham operation group（n=20）.The vascular dementia model was established by bilateral common carotid artery ligation.The changes of the spatial learning and memory ability were evaluated by Morris water maze test.The brains were removed to detect the content of AchE,CHAT,SOD and MDA.Results：Compared with vascular dementia group,the learning and memory ability of rats in vascular dementia intervention group were increased,the escape latency were significantly shortened,the number of across the platform after remove platform was increased.The content of AchE and MDA were much lower,that of CHAT and SOD were much higher in vascular dementia intervention group（P〈0.05）.Conclusion：Idebenone could improve learning and memory ability in rats with vascular dementia.Its mechanism might relate to reducing the level of oxidative stress and enhancing the function of cholinergic neurons.

关 键 词：痴呆 血管性/药物作用 记忆/药物作用 苯醌类/治疗应用 乙酰胆碱酯酶/代谢 丙二醛/代谢 胆碱乙酰转移酶/代谢 模型 动物 大鼠 

分 类 号：R734.1[医药卫生—肿瘤]