单鼻孔经蝶内镜手术与显微镜手术治疗生长激素型垂体腺瘤的疗效比较  

Efficacy comparison of single nostril transsphenoidal endoscopic surgery and microsurgery in the treatment of growth hormone-secreting pituitary adenoma

作　　者：李全才[1] 黄斌[1] 张庭荣[1] 郭运发[1] 吴昊[1] 罗坤[1] 

机构地区：[1]新疆医科大学第一附属医院神经外科,乌鲁木齐830054

出　　处：《中国微侵袭神经外科杂志》2016年第4期145-147,共3页Chinese Journal of Minimally Invasive Neurosurgery

基　　金：新疆维吾尔自治区高技术研究项目(编号:201417103)

摘　　要：目的比较内镜手术与显微镜手术在切除生长激素型垂体腺瘤的有效性及安全性。方法回顾性分析195例生长激素型垂体腺瘤病人的临床资料,其中单鼻孔经蝶内镜手术94例(内镜组),单鼻孔经蝶显微镜下手术101例(显微镜组)。比较两种手术方式的安全性及有效性。结果两组的肿瘤切除程度、手术时间、术后2年复发率没有统计学差异(P>0.05)。与显微镜组比较,内镜组病人术后生长激素恢复更好,并发症发生率低,住院时间短(P<0.05)。结论对于生长激素型垂体腺瘤病人,单鼻孔经蝶入路神经内镜手术优于显微镜手术。Objective To explore the efficacy and safety of endoscpic surgery and microsurgery for the removal of growth hormone-secreting pituitary adenoma（GHPA）. Methods Clinical data of 195 GHPA patients were analyzed retrospectively. The single nostril transsphenoidal endoscopic surgery was performed on 94 patients（endoscopic group） and the single nostril transsphenoidal microsurgery on 101（microscope group）. The safety and efficacy were compared between the two patient groups. Results There were no significant differences in resection extent of tumors, surgical time and recurrence rate 2 years after surgery between the two groups（P〉0.05）. Compared with microscope group, the recovery of growth hormone was better, the incidence of complications was lower and hospital stay was shorter in endoscopic group（P〈0.05）. Conclusions For GHPA patients, the single nostril transsphenoidal endoscopic surgery is superior to microsurgery.

关 键 词：垂体肿瘤 生长激素 入路 经鼻蝶 神经内镜 显微镜 研究 对比 

分 类 号：R736.4[医药卫生—肿瘤] R651.11[医药卫生—临床医学]