氟哌噻吨美利曲辛联合曲美布汀治疗伴有焦虑抑郁的肠易激综合征患者的疗效评估  

Therapeutic effects of flupentixol and melitracen combined with trimebutine in patients with irritable bowel syndrome accompanied with anxiety and depression

作　　者：韩静[1] 孙光斌 张宝芹[1] 王柏清[1] 李甜甜[1] 

机构地区：[1]天津市第五中心医院消化内科,天津市300450

出　　处：《世界华人消化杂志》2016年第12期1916-1920,共5页World Chinese Journal of Digestology

摘　　要：目的:观察氟哌噻吨美利曲辛联合曲美布汀治疗伴有焦虑抑郁状态的腹痛明显的肠易激综合征(irritable bowel syndrome,IBS)患者的疗效.方法:本研究为多中心、随机、前瞻性研究,将纳入的48例患者分为联合治疗组(24例)和对照组(24组).两者均口服曲美布汀,其中联合治疗组加用氟哌噻吨美利曲辛,疗程为4 wk,于治疗前、治疗1、4 wk同时进行胃肠道症状和情绪障碍评估.统计学分析采用卡方检验.结果:治疗后1 wk,联合治疗组与对照组的胃肠道症状改善有效率分别为16.7%和20.8%(P>0.05);治疗后4 wk,联合治疗组的胃肠道症状改善有效率为87.5%,高于对照组的41.7%(冇2=9.507,P=0.002).治疗后1 wk,联合治疗组与对照组的汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)评分有效率分别为14.3%和9.09%,汉密尔顿焦虑量表(Hamilton Anxiety Scale,HAMA)评分有效率为25.0%和22.2%(P>0.05),治疗后4 wk,联合治疗组与对照组的HAMD评分有效率分别为61.9%和22.7%(冇2=6.776,P=0.009),HAMA评分有效率为66.7%和33.3%(冇2=4.582,P=0.032).结论:氟哌噻吨美利曲辛联合曲美布汀不仅可以有效改善腹痛明显的IBS的焦虑抑郁症状,还可有效改善患者的消化系症状,效果明显优于曲美布汀治疗.AIM：To assess the therapeutic effects of flupentixol and melitracen tablets combined with trimebutine in patients with abdominal pain-predominant irritable bowel syndrome（IBS） accompanied with anxiety and depression.METHODS：This multi-center,randomized,prospective study enrolled 48 patients with abdominal pain-predominant IBS who were divided into either a combination treatment group（24 patients） or a control group（24patients）.Trimebutine was administrated in both groups,while flupentixol and melitracen was added in the combination treatment group.The treatment lasted 4 wk.Gastrointestinal symptoms and mood disorders were evaluated before treatment,1 wk and 4 wk after treatment.RESULTS：At the end of one week after treatment,the rates of improvement of gastrointestinal symptoms in the combination treatment group and control group were 16.7% and 20.8%,and there was no statistically signifi cant difference between them（P〉 0.05）.At the end of 4 wk after treatment,the rates of improvement of gastrointestinal symptoms in the combination treatment group was 87.5%,which was significantly higher than that of the control group（41.7%;冇2 = 9.507,P = 0.002）.At the end of 1 week after treatment,there were no statistically signifi cant differences in the rates of Hamilton Depression Scale score improvement（14.3% and 9.09%,P 〈0.05） or the rates of Hamilton Anxiety Scale score improvement（25.2% vs 22.2%,P 〈0.05） between the combination treatment group and control group.At the end of 4 weeks after treatment,the rate of Hamilton Depression Scale score improvement in the combination treatment group was significantly higher than that of the control group（61.9% vs 22.7%,X^2 = 6.776,P =0.009）,and the rate of Hamilton Anxiety Scale score improvement was also signifi cantly higher in the combination treatment group（66.7% vs33.3%,X^2 = 4.582,P = 0.032）.CONCLUSION：Flupentixol and melitracen combined with trimebutine could not only improve the anxiety and depression symptoms of patients wi

关 键 词：肠易激综合征 焦虑 抑郁 曲美布汀 氟哌噻吨美利曲辛 

分 类 号：R574.4[医药卫生—消化系统] R749.2[医药卫生—内科学]