慢性B淋巴细胞白血病、肾脏淀粉样变性合并C3肾小球病  

B-cell chronic lymphocytic leukemia,kidney amyloidosis with C3 glomerulopathy

作　　者：张志宏[1] 谢红浪[1] 刘志红[1] 

机构地区：[1]南京军区南京总医院肾脏科国家肾脏疾病临床医学研究中心全军肾脏病研究所,南京210016

出　　处：《肾脏病与透析肾移植杂志》2016年第2期195-200,共6页Chinese Journal of Nephrology,Dialysis & Transplantation

摘　　要：老年男性患者,临床表现肾病综合征,血清单克隆游离轻链比例异常,免疫固定电泳见κ型Ig G单克隆免疫球蛋白条带,肾活检病理提示肾淀粉样变性合并C3肾小球病,间质大量CD20+细胞浸润。骨髓穿刺及活检提示淋巴浆细胞高度增生。结合临床、病理最终诊断慢性B淋巴细胞白血病、肾淀粉样变性合并C3肾小球病。A 68-year-old man was admitted for nephrotic syndrome. His serum free light chain ratio was abnormal,and immunofixation electrophoresis test was positive. His renal biopsy revealed amylodiosis with C3 deposition,renal interstitial infiltrating lymphocytes that were positive of CD20. Bone marrow puncture and biopsy revealed abnormal Bcell lymphoproliferation. The final diagnosis for the case was B-cell chronic lymphocytic leukemia（ B-CLL）,renal amyloidosis with C3 glomerulopathy.

关 键 词：B淋巴细胞白血病 肾淀粉样变性 C3肾小球病 

分 类 号：R733.72[医药卫生—肿瘤]