核糖核苷酸还原酶小亚基M2在宫颈鳞癌组织中的表达及临床意义  

Expression of ribonucleotide reductase subunit M2 in cervical squamous-cell carcinoma tissues

作　　者：金闺秀[1] 杨海涛 林毅[3] 钟惠珍[3] 

机构地区：[1]台州市第一人民医院妇产科,318020 [2]宁波市临床病理诊断中心 [3]宁波市妇女儿童医院妇产科

出　　处：《浙江医学》2016年第8期548-550,554,共4页Zhejiang Medical Journal

基　　金：浙江省医药卫生一般研究计划(2014KYB241)

摘　　要：目的探讨核糖核苷酸还原酶小亚基M2（RRM2）在宫颈鳞癌中的表达。方法采用免疫组化法检测20例宫颈上皮内瘤变2-3级组织、68例宫颈鳞癌组织和18例正常宫颈组织中RRM2蛋白表达，并分析与临床病理参数及肿瘤标志物之间的关系。结果RRM2在宫颈鳞癌组织中蛋白阳性表达率为82．35％。明显高于宫颈上皮内瘤变组织（55．00％）和正常宫颈组织（11．11％）。3组问差异有统计学意义（P〈0．05）。不同组织分化程度、血清鳞状细胞癌抗原（SCC）阳性与否的宫颈鳞癌患者RRM2蛋白阳性表达率差异均有统计学意义（均P〈0．01），即高分化组低于中、低分化组，SCC阳性组高于SCC阴性组。结论RRM2在宫颈鳞癌组织中高表达，且组织分化低、血清SCC阳性者的RRM2蛋白阳性表达率偏高。Objective To investigate protein expression of ribonucleotide reductase subunit M2 （RRM2） in cervical squamous-cell carcinoma. Methods The expression of RRM2 was detected by immunohistochemistry staining in 68 specimens of cervical squamous-cell carcinoma, 20 specimens of cervical intraepithelial neoplasm （CIN）and 18 specimens of normal cervical tissue. The relationship of RRM2 expression with clinicopathology features and tumor biomarkers was analyzed. Results The positive RRM2 expression rate in cervical squamous-cell carcinoma tissue （82.35%）was significantly higher than that in CIN （55.00%） and normal cervical tissue （11.11%）（P〈0.05）. The positive expression rate of RRM2 in well-differentiated carcinoma was lower than that in moderately- and poorly- differentiated carcinoma. The expression of RRM2 in serum squamous cell carcinoma antigen （SCCA）positive group was higher than that in SCCA negative group （P〈0.01）. Conclusion The overexpression of RRM2 is found in cervical squamous-cell carcinoma, in particular, in those with lower differentiation degree and with positive serum SCCA.

关 键 词：宫颈鳞癌 核糖核苷酸还原酶M2 免疫组化 鳞癌相关抗原 

分 类 号：R737.33[医药卫生—肿瘤]