急性脑出血患者颈动脉斑块与血清hs-CRP及HbAlc的相关性研究  

Acute Cerebral Hemorrhage:Correlation of Serum hs-CRP,Hb Alc and Carotid Atherosclerosis Plaque

作　　者：常久魁 刘晓荣 郑建辉[1] 周晋[1] 刘维田[1] 徐雅彪 张国栋[1] 

机构地区：[1]唐山市丰润区人民医院脑二科,河北唐山064000 [2]唐山市丰润区中医院中风一科,河北唐山064000

出　　处：《现代生物医学进展》2016年第13期2530-2532,2547,共4页Progress in Modern Biomedicine

摘　　要：目的:探究急性脑出血患者颈动脉斑块与血清超敏C反应蛋白(hs-CRP)及糖化血红蛋白(Hb Alc)的相关性。方法:随机选取我院2013年5月至2015年1月脑科收治的急性脑出血患者84例,根据颈动脉粥样硬化标准将所有患者分为单纯脑出血组(n=25)、轻度粥样硬化组(n=34)和重度粥样硬化组(n=25)三组,另选取同期我院健康体检者50人(对照组)。对比分析四组颈总动脉膜厚度(IMT)空腹血糖(FPG)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、hs-CRP与Hb Alc水平,分析急性脑出血患者颈动脉斑块的危险因素。结果:四组的IMT、TC、TG、HDL、LDL、hs-CRP和Hb Alc水平差异均具有统计学意义(P<0.05),其中hs-CRP和Hb Alc水平在单纯脑出血组<轻度粥样硬化组<重度粥样硬化组(P<0.05);IMT与hs-CRP和Hb Alc均呈现正相关(r=0.388、0.420,P<0.05);IMT、hs-CRP和Hb Alc均为颈动脉粥样硬化的危险因素(OR=3.065、1.978、1.647,P<0.05)。结论:急性脑出血患者体内hs-CRP及Hb Alc水平是颈动脉斑块形成的危险因素。Objective： To explore the correlation of serum high sensitivity C-reactive protein （hs-CRP）, glycated haemoglobin （HbAlc） and carotid atherosclerosis plaque in patients with acute cerebral hemorrhage. Methods： A total of 84 patients with acute cerebral hemorrhage, who were admitted to People＇s Hospital of Fengrun District from May 2013 to January 2015, were selected and randomly di- vided into acute cerebral hemorrhage group （n=25）, mild atherosclerosis group （n=34） and severe atherosclerosis group （n=25）, and 50 healthy people were chosen as control group in the same period. Then the intima-media thickness（IMT）, fasting plasma glucose（FPG）, tri- acylglyceride（TG）, total cholesterol（TC）, low density lipoprotein（LDL）, high density lipoprotein（HDL）, hs-CRP and HbAlc of the four groups were compared, and the risk factors of carotid atherosclerosis plaque were analyzed. Results： There were statistical differences in the levels of IMT, TC, TG, HDL, LDL, hs-CRP and HbAlc between the four groups （P〈0.05）. IMT was positively correlated with hs-CRP and HbAlc （r=0.388,0.420, P〈0.05）. IMT, hs-CRP and HbAlc were the risk factors of carotid atherosclerosis plaque（OR=3.065, 1.97, 1.647, P〈0.05）. Conclusion： hs-CRP and HbAlc in patients with acute cerebral hemorrhage are the risk factors of formation of carotid atherosclerosis plaque.

关 键 词：急性脑出血 血清超敏C反应蛋白 糖化血红蛋白 

分 类 号：R743.34[医药卫生—神经病学与精神病学]