非小细胞肺癌患者胸膜转移瘤中NOK的表达及其与生存期的相关性  

The Expression of NOK in NSCLC Patients with Pleural Metastases and Its Correlation with Survival Period

作　　者：王居正[1] 孙盈[1] 邢昊[1] 邹鑫[2] 刘子凡[2] 张志培[1] 周勇安[1] 卢强[1] 陈召[1] 李小飞[1] 

机构地区：[1]第四军医大学唐都医院胸腔外科,陕西西安710038 [2]第四军医大学学员一旅,陕西西安710049

出　　处：《现代生物医学进展》2016年第14期2663-2666,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81572252)

摘　　要：目的:探讨非小细胞肺癌(NSCLC)患者胸膜转移瘤中NOK表达及其与患者生存期的相关性。方法:选取我科2014年至2015年收治的Ⅳ期NSCLC患者67例,用软式胸腔镜取胸膜转移瘤和瘤旁胸膜,采用免疫组化法测定NOK的表达情况,分析胸膜转移瘤和瘤旁胸膜中NOK的表达的无差异性;对患者进行随访,并分析胸膜转移瘤和瘤旁胸膜中NOK的表达与患者生存期的相关性。结果:1Ⅳ期NSCLC患者胸膜转移瘤中NOK的表达明显高于瘤旁胸膜,具有统计学差异(P<0.05);2Ⅳ期NSCLC患者胸膜转移瘤中NOK的表达量与患者的生存期呈负相关,瘤旁胸膜中NOK的表达量与患者的生存期无显著相关性。结论:NSCLC患者胸膜转移瘤中NOK的表达异常上调,且与患者的生存期呈负相关,可做为判断Ⅳ期NSCLC患者生存期的参考指标。Objective： To investigate the NOK expression in NSCLC patients and its correlation with the prognosis. Methods： 67 cases of NSCLC patients at stage IV with pleural metastases who admitted in our division from 2014 to 2015 were selected, and metastatic tumor of pleura and pleura beside the tumor were obtained using soft thoracoscopic, then the expression of NOK in the two kinds of issues were detected by immunohistochemistry, then the correlation of NOK expression in metastatic tumor of pleura and pleura beside the tumor with the prognosis of patients were analyzed. Results： OThe expression of NOK in metastatic tumor of pleura was apparently higher than that from pleura beside the tumor （P〈0.05）; （2）The expression of NOK in metastatic tumor of pleura was inversely related to the survival period of patients （P〈0.05）, while there was no significant relationship between the expression of NOK in pleura beside the tumor and survival of patients. Conclusions： The expression of NOK in metastatic tumor of pleura was inversely related to the survival period of NSCLC patients at stage IV, which could be used as the standard for assessing the survival of NSCLC patients at stage IV.

关 键 词：非小细胞肺癌 胸膜转移瘤 NOK 生存期 

分 类 号：R734.3[医药卫生—肿瘤]