PF方案同步放化疗治疗中晚期宫颈癌的疗效及毒性反应研究  

Efficacy and Toxicity of PF Regimen Concurrent Radiotherapy and Chemotherapy in the Treatment of Patients with Advanced Cervical Cancer

作　　者：都成[1] 齐跃[1] 刘水策[1] 杨琳[1] 杨雪崴 

机构地区：[1]中国医科大学附属盛京医院妇产科,辽宁沈阳110004

出　　处：《现代生物医学进展》2016年第14期2711-2713,2617,共4页Progress in Modern Biomedicine

基　　金：辽宁省自然科学基金项目（2014021021）

摘　　要：目的：探究PF方案同步放化疗治疗中晚期宫颈癌患者的疗效和毒性反应。方法：回顾性分析我院在2014年6月~2015年6月期间收治的ⅡB~Ⅲ期宫颈癌患者,共152例,根据治疗方法将其分为单纯放疗组和同步放化疗组,比较两组患者治疗的疗效和毒性反应。结果：单纯放疗组和同步放化疗组近期疗效总有效率无显著差异,差异不具有统计学意义（P〉0.05）,但分别对ⅡB和Ⅲ期患者进行分析,Ⅲ期患者同步放疗组总有效率显著高于单纯放疗组,差异具有统计学意义（P〈0.05）;同步放化疗组患者治疗后骨髓抑制白细胞下降和消化道反应发生率显著高于单纯放疗组,差异具有统计学意义（P〈0.05）,两组患者皮肤反应的发生情况比较无显著差异（P〉0.05）。结论：PF方案同步放化疗治疗Ⅲ期宫颈癌的临床疗效显著优于单纯放疗治疗,可有效提高近期总有效率,毒性反应虽较单纯放疗组有所增加,但经临床支持治疗患者均可耐受。Objective： To explore the efficacy and toxicity of PF regimen concurrent radiotherapy and chemotherapy in the treatment of patients with advanced cervical cancer. Mothods： A retrospective analysis was performed on 152 cases of cervical cancer patients at stage IIB to stage HI admitted in our hospital fxom June 2014 to June 2015, According to the methods of treatment, all the patients were divided into the radiotherapy alone group and concurrent radiotherapy and chemotherapy. The efficacy and toxicity were observed and compared between two groups. R^sults： No significant difference was found in the short-term efficacy between teo goups （P〉0.05）. But for cervical cancer patients at stage IIB to stage III, the clinical efficacy of concurrent radiotherapy and chemotherapy group was significantly higher than that of radiotherapy alone group （P〈0.05）; the incidence of bone marrow suppression and digestive tract reaction of concurrent radiotherapy and chemotherapy group were significantly higher than that of radiotherapy alone group （P〈0. 05）, but no significant difference was observed in the incidence of skin reactions between two groups （P〉0.05）. Conclusions： PF regimen concurrent radiotherapy and chemotherapy treatment was superior to radiotherapy alone in for stage HI cervical cancer patients, it could effectively improve the short-term efficiency, although the toxicity was more, the clinical support treatment of patients were tolerable.

关 键 词：PF方案 放化疗 中晚期宫颈癌 疗效 毒性反应 

分 类 号：R737.33[医药卫生—肿瘤]