血清血管内皮生长因子表达与局部晚期食管癌调强适形放疗同步化疗效果的关系  

Relationship between expression of serum vascular endothelial growth factor and efficacy of local advanced esophageal carcinoma treated with intensity-modulated radiotherapy combined with chemotherapy

作　　者：徐燕[1] 王栾秋 于兰[1] 张建旭[1] 

机构地区：[1]山东省青岛市肿瘤医院放疗二科,266042

出　　处：《肿瘤研究与临床》2016年第4期248-250,261,共4页Cancer Research and Clinic

摘　　要：目的检测局部晚期食管癌患者采用调强适形放疗同步多西他赛联合奈达铂化疗治疗前后血清血管内皮生长因子（VEGF）表达水平，探讨其变化规律及其与近期疗效的关系和意义。方法采用酶联免疫吸附法（ELISA）检测46例局部晚期食管癌患者化疗联合同步放疗前后血清VEGF表达水平，同时检测46名健康人血清VEGF表达水平。比较两组VEGF表达水平及VEGF与疗效的关系。结果局部晚期食管癌患者治疗前与健康对照组血清VEGF表达水平分别为（264．66±62．11）、（101．96±39．53）ng／L，差异有统计学意义（t=23．367，P=0．000）。食管癌患者治疗后血清VEGF水平降至（127．50±49．07）ng／L，与治疗前相比，差异有统计学意义（t=19．086，P=0．000）。与治疗前比较，治疗后完全缓解组、部分缓解组VEGF水平降低[（94．03±38．86）ng／L比（248．79±47．84）ng／L，（117．06±20．68）ng／L比（295．26±67．20）ng／L，均P=0．000]，稳定组也有所降低[（235．63±26．05）ng／L比（385．67±26．50）ng／L，P=0．017]。结论调强适形放疗同步多西他赛联合奈达铂化疗治疗局部晚期食管癌近期疗效明显。检测治疗前后血清VEGF表达水平可作为判断肿瘤治疗效果的重要指标。Objective To investigate the expression of serum vascular endothelial growth factor （VEGF） in local advanced esophageal carcinoma patients, and to explore the relationship between its change rule and the recent curative effect and significance. Methods The serum levels of VEGF in 46 patients with local advanced esophageal carcinoma were detected by ELISA before and after concurrent chemoradiotherapy, the serum levels of VEGF in 46 healthy people were detected at the same time. Results The serum VEGF levels of local advanced esophageal carcinoma patients before treatment and health control group were （264.66±62.11） ng/L and （101.96±39.53） ng/L, and the difference was statistically significant （t = 23.367, P = 0.000）. After treatment, the serum VEGF level of patients with esophageal cancer was decreased to （127.50±49.07） ng/L （t = 19.086, P = 0.000）. After the treatment, the serum VEGF levels of complete remission （CR） and partial remission （PR） patients were decreased [（94.03±38.86） ng/L vs （248.79±47.84） ng/L, （117.06±20.68） ng/L vs （295.26±67.20） rig/L, both P = 0.000], the level of the stable disease （SD） patients was decreased, too [（235.63±26.05） ng/L vs （385.67±26.50） rig/L, P = 0.017]. Conclusions The recent curative effects of docetaxel and nedaplatin chemotherapy combined with intensity-modulated radiotherapy for the local advanced esophageal carcinoma patients are significant. The levels of serum VEGF before and after treatment can be used as an important index to judge the treatment effect.

关 键 词：食管肿瘤 药物疗法 放射疗法 调强适形 血管内皮生长因子类 

分 类 号：R735.1[医药卫生—肿瘤]