端粒、端粒酶及人端粒酶反转录酶在肿瘤中的研究进展  

Research progress of telomere,telomerase and human telomerase reverse transcriptase in tumors

作　　者：赵盼[1] 刘真 管静芝[1] 

机构地区：[1]解放军第三0九医院肿瘤科,北京100091 [2]解放军第三0九医院烧伤整形科,北京100091

出　　处：《肿瘤研究与临床》2016年第4期284-287,共4页Cancer Research and Clinic

基　　金：国家自然科学基金，解放军第三○九医院院管课题，全军医学科技青年培育项目(15QNP049)National Natural Science Foundation of China，Hospital Management Project of the 309th Hospital of PLA，Military Medical Science and Technology Youth Training Program

摘　　要：端粒和端粒酶共同维持染色体的结构和功能稳定，研究发现它们与人类肿瘤的发生、发展密切相关。端粒是真核生物染色体末端的脱氧核糖核酸，维持染色体的完整；端粒酶是一种特异的核蛋白结构，可延长端粒并维持端粒稳定，与细胞的无限增殖和癌变直接相关；人端粒酶反转录酶（hTERT）既是端粒酶的重要组成部分，又是端粒酶的限速亚单位，直接决定端粒酶的活性。进一步研究端粒、端粒酶及hTERT的结构、功能及相互作用，有助于了解肿瘤的发生、发展机制，对肿瘤的诊断和治疗意义重大，并且可以为肿瘤治疗提供新靶点。Telomere and telomerase maintain the stability of chromosome in structure and function. Studies have found that they are closely related with the development of human tumors. Telomeres are deoxyribonucleic acid in the terminal of chromosome of eukapyotes to maintain the integrity of chromosome. Telomerase is a kind of special structure of nucleoprotein, it prolongs the telomere and maintains the telomere＇s stability, and it is directly related to the unlimited proliferation and canceration of ceils. Human telomerase reverse transcriptase （hTERT） is both the important component and speed limit subunit of telomerase, it directly determines the telomerase activity. Further studies on structure, function and interaction of telomere, telomerase and hTERT help understand the developing mechanisms of tumors, they have important significance to the tumor diagnosis and treatment, and can provide new targets for cancer treatment.

关 键 词：肿瘤 端粒 端粒酶 人端粒酶反转录酶 

分 类 号：R730.2[医药卫生—肿瘤]