术中腹腔缓释化疗对胃癌根治手术患者预后的影响  

Intraoperative intraperitoneal chemotherapy in radical surgery sustained impact on the prognosis of patients With gastric cancer

作　　者：张大伟[1] 李莹[1] 陈宗祐[2] 

机构地区：[1]复旦大学附属金山医院普外科,上海201508 [2]复旦大学附属华山医院普外科

出　　处：《中国综合临床》2016年第4期315-318,共4页Clinical Medicine of China

基　　金：复旦大学附属金山医院科研项目（2013-14）

摘　　要：目的探讨术中腹腔中人氟安缓释化疗对胃癌根治手术患者预后的影响。方法选取2011年6月至2012年9月我院收治的胃癌患者100例，依据随机数表法分为观察组（胃癌根治术＋中人氟安缓释化疗）与对照组（单纯胃癌根治术），比较两组患者治疗前、治疗后7d相关生化指标、并发症发生情况及生存率。结果两组患者治疗前后的WBC、PLT、TBIL、SCr等生化指标的组间比较差异均无统计学意义（P均〉0．05）。两组患者化学性腹膜炎、粘连性肠梗阻、吻合口瘘、肠穿孔等并发症的发生率比较差异均无统计学意义（P均〉0．05）。对照组患者半年、1年、2年生存率分别为87．50％、80．00％、62．50％，无瘤生存率分别为75．00％、55．00％、35．00％；观察组患者半年、1年、2年生存率分别为96．67％（χ2=6．108，P=0．014）、90．00％（χ2=8．796，P=0．003）、78．33％（χ2=4．579，P=0．032），无瘤生存率分别为93．33％（χ2=3．902，P=0．045）、86．67％（χ2=6．635，P=0．010）、70．00％（χ2=5．203，P=0．021），两组比较差异均有统计学意义。结论术中腹腔缓释化疗对胃癌根治手术患者无不良影响，且能有效提高术后无瘤生存率，值得临床推广。Objective o explore intraperitoneal human fluorine safe release chemotherapy after radical surgery on the prognosis of patients with gastric cancer. Methods One hundred gastric cancer patients who weretreated in Jinshan Hospital Affiliated to Fudan University from June 2011 to September 2012 were selected and divided into observation groups （gastrectomy ＋ Human fluorine An chemotherapy） and control group （simple gastrectomy） according to a random number table method. Biochemical index before treatment and 7 d after treatment, complication occurrence and survival rate of two groups were compared. Results There were no statistically significant differences in terms of WBC, PLT, IBIL, Cr and other biochemical markers before and after treatment between the two groups （ P 〉 0. 05） . There were statistically significant differences in terms of chemical peritonitis, intestinal obstruction, fistula, intestinal perforation and other complications between two groups （ P〉 0. 05） . The 6 months, 1 year, 2-year survival rates of control group were 87.50%, 80. 00%, 62.50%, of observation group were 96. 67%, 90.00%, 78. 33%, the differences were significant （ χ2 = 6. 108,8.796, 4.579;P= 0.014,0.003,0.032） .The 6 months, 1 year, 2-year free survival rates of control group were 75.00%, 55.00%, 35.00%, of observation group were 93.33%, 86. 67%, 70. 00%, the differences were significant（ χ2 = 3. 902,6. 635,5. 203 ; P = 0. 045,0. 010,0. 021 ） . Conclusion Intraoperative intraperitoneal chemotherapy sustained radical surgery in patients with no adverse effects on the stomach, can effectively improve the postoperative survival rates, worthy of promotion.

关 键 词：中人氟安 胃癌根治术 生存率 

分 类 号：R735.2[医药卫生—肿瘤]