血管紧张素原基因AGT M235T多态性与脑白质疏松症相关性研究  

Association of the polymorphism of angiotensinogen gene M235T leukoaraiosis

作　　者：孙丽伟 周卫东 刘承浩 杨芳 王君 汪琦 任歆 尹晓明 曾庆玉 

机构地区：[1]煤炭总医院神经内科,北京100028 [2]煤炭总医院影像科,北京100028

出　　处：《中风与神经疾病杂志》2016年第4期303-306,共4页Journal of Apoplexy and Nervous Diseases

基　　金：首都卫生发展科研专项(No.2011-6011-01)

摘　　要：目的探讨肾素血管紧张素原(angiotensinogen,AGT)M235T基因多态性与脑白质疏松症(Leukoaraiosis,LA)的相关性。方法采用聚合酶链反应(PCR)及聚合酶链反应-限制片段长度多态性(PCR-RFLP)及Sequenom系统检测,经头部MRI确诊的202例脑白质疏松症患者及105例经MRI排除LA的正常对照者AGTM235T基因多态性。结果脑白质疏松症患者AGTMT基因型及T等位基因频率与对照组有明显差异,两组间TT基因型差异无统计学意义。结论 AGT基因MT基因型和T等位基因可能与脑白质疏松症的发病相关。Objective To study the relationship between polymorphisms of angiotensinogen AGT（ M235T） gene and leukoaraiosis. Methods A case control study was carried out using 202 cases of leukoaraiosis（ LA group） and 105 cases of control. The M235 T polymorphisms gene were determined by polymerase chain reaction（ PCR）-restriction fragment length polymorphism（ PFLP） technique and sequenom system test. Results There was a statistical difference in AGT MT genotypes and T alleles frequency between leukoaraiosis group and control subjects. The difference of AGT TT genotypes between the two groups had no statistical significance. Conclusion The mutation of AGT MT genotypes and T alleles frequency may be associated with leukoaraiosis.

关 键 词：脑白质疏松症 基因多态性 血管紧张素原 脑小血管病 

分 类 号：R742[医药卫生—神经病学与精神病学]