放疗联合吉西他滨加顺铂同步与序贯放化疗对Ⅲ期不能手术非小细胞肺癌疗效对比研究  

Comparison of the efficacy of radiotherapy combined with gemcitabine plus cis-platin concurrent or sequential chemoradiotherapy for inoperable stage III non-small cell lung cancer

作　　者：沙晓锋[1] 张姣[1] 韦淑贞[1] 

机构地区：[1]中国人民解放军第八二医院肿瘤科,江苏淮安223001

出　　处：《中国医学前沿杂志（电子版）》2016年第4期49-52,共4页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：目的分析放疗联合吉西他滨加顺铂同步与序贯放化疗对Ⅲ期不能手术非小细胞肺癌的疗效。方法选取2011年5月至2013年5月本院收治的70例Ⅲ期不能手术非小细胞肺癌患者为研宄对象,按照患者入院顺序将其分为观察组和对照组,观察组患者采取同步放化疗,对照组患者采取序贯放化疗。观察并比较两组患者治疗前后血清CD44v6和血管内皮生长因子(VEGF)水平、生活质量评分、近期疗效、不良反应发生情况及生存率。结果治疗前两组患者CD44v6和VEGF水平比较均无显著差异(P>0.05);治疗后观察组患者CD44v6和VEGF水平均明显低于对照组(P<0.05),治疗总有效率明显高于对照组(P<0.05),不良反应发生情况与对照组比较无显著差异(P>0.05)。两组患者治疗后生活质量评分与治疗前相比总体呈下降趋势,但治疗结束后可基本恢复至治疗前水平,且观察组与对照组比较无显著差异(P>0.05)。观察组患者2年生存率明显高于对照组(P<0.05)。结论与序贯放化疗相比,放疗联合吉西他滨加顺铂同步放化疗治疗Ⅲ期不能手术非小细胞肺癌效果显著,能够显著提高患者的远期生存率,但药物不良反应较大。Objective To observe and analyze the clinical effect of radiotherapy combined with gemcitabine plus cis-platin concurrent or sequential chemoradiotherapy for inoperable stage Ⅲ non-small cell lung cancer（NSCLC）.Method Chose 70 cases of inoperable patients with stage Ⅲ NSCLC from May 2011 to May2013 treated in our hospital,and divided into observation group and control group according to the order of hospitalization.Observation group patients were treated with concurrent chemoradiotherapy,and control group patients were treated with sequential chemoradiotherapy.Observed and compared serum CD44v6 and VEGF levels,quality of life score,the short-term efficacy,adverse reactions and survival rate before and after treatment between the two groups.Result There were no significant differences in the levels of CD44v6 and VEGF before treatment between the two groups（P 〉0.05）.After treatment,the levels of CD44v6 and VEGF of observation group were significantly lower than control group（P 〈0.05）;the total effect rate（short term） of observation group was significantly higher than control group（P 〈0.05）;adverse reaction rates between the two groups had no statistical difference（P 〉0.05）.The life quality of both groups showed an overall downward trend after treatment compared to their life quality before treatment,but the quality of life returned to pre-treatment levels when the treatment process done.And the difference in life quality between the two groups was not significant（P 〉0.05）.After 2 year follow-up,the survival rate of observation group was higher than control group {P〈 0.05）.Conclusion Compared with sequential chemoradiotherapy,radiotherapy combined with gemcitabine plus cis-platin concurrent chemoradiotherapy has a better effect on treating inoperable patients with stage Ⅲ NSCLC and can significantly improve long-term survival of patients.However,the drug adverse reactions also exist more.

关 键 词：同步放化疗 序贯放化疗 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]