白细胞介素35的在肿瘤发展中的作用  

Current Research of the Roles of IL-35 in Tumor Progression

作　　者：黄崇标[1] 田野[1] 崔焱[1] 徐杰[1] 辛亮[1] 杨雪玲[2] 齐大亮[1] 

机构地区：[1]国家癌症临床研究中心,天津市肿瘤防治重点实验室,天津医科大学肿瘤医院高级病房,天津300060 [2]国家癌症临床研究中心,天津市肿瘤防治重点实验室,天津医科大学肿瘤医院介入治疗肿瘤科,天津300060

出　　处：《中国肺癌杂志》2016年第4期230-235,共6页Chinese Journal of Lung Cancer

基　　金：国家自然科学基金项目(No.81501568)资助

摘　　要：白细胞介素(interleukin,IL)-35是IL-12细胞因子家族的新成员,自2007年发现以来IL-35很快成为了相关领域的研究热点。与IL-12家族的其他成员(IL-12、IL-23以及IL-27)相类似,IL-35也是由异源性的α链及β链组成,即p35和EBI3蛋白组成。目前的研究发现IL-35的功能主要表现在两个方面,一方面是IL-35在体内某些炎性疾病及自身免疫性疾病患者体内异常表达,IL-35在这些疾病的发生发展过程中起到重要作用。另一方面,IL-35在某些肿瘤中也表达异常,在肿瘤的发展过程中起到了重要作用。本文对IL-35的结构及信号通路进行了阐述,并总结了IL-35在肿瘤发展中的作用的最新研究进展。Interleukin（IL）-35 is a new member of the interleukin-12 superfamily. Since its first report in 2007, IL-35 rapidly became a research highlight in the ifeld of immunology. Like other IL-12 superfamily members, IL-35 was a heterodimer which was composed of anαchain P35 and aβchain Epstein-Barr virus induced gene 3 （EBI3）. Recent research work revealed two distinct roles of IL-35. Firstly, IL-35 is highly expressed in some kinds of inlfammatory diseases and autoim-mune diseases and plays import roles in the pathogenesis. Secondly, IL-35 is positively expressed in some cancers and plays some roles in the process of tumor progression. Here we demonstrate the structure and the signalling of IL-35. We reviewed the the roles of IL-35 in promoting tumor progression.

关 键 词：白细胞介素 IL-35 肿瘤 肿瘤免疫 

分 类 号：R730.21[医药卫生—肿瘤]