前列腺癌术后病理较穿刺病理Gleason评分升高的相关因素  

A control study on correlated factors of Gleason score upgrading in a contemporary cohort underwent radical prostatectomy after extended prostate biopsy

作　　者：何必鸣 陈锐[1] 高旭[1] 任善成[1] 杨波[1] 侯建国[1] 王林辉[1] 杨庆[1] 周铁[1] 赵琳[1] 许传亮[1] 孙颖浩[1] 

机构地区：[1]第二军医大学附属长海医院泌尿外科,上海200433

出　　处：《中华腔镜泌尿外科杂志（电子版）》2016年第2期4-6,共3页Chinese Journal of Endourology(Electronic Edition)

基　　金：国家重点基础研究发展(973)计划项目(2012CB518306)

摘　　要：目的探讨影响前列腺癌术后病理Gleason评分较穿刺病理Gleason评分升高的相关因素。方法回顾性选择第二军医大学附属长海医院自2014年1月至2015年6月的102例前列腺癌根治术患者,收集可能影响Gleason评分升高的相关因素资料,采用单因素和多因素Logistic回归筛选影响Gleason评分升高的因素。结果单因素Logistic回归分析显示年龄、体质量指数(BMI)、前列腺特异性抗原(PSA)、前列腺体积、PSA密度(PSAD)与直肠指诊(DRE)等相关指标无显著统计学意义(P>0.05);多因素logistic回归分析结果显示前列腺体积对于前列腺癌术后病理Gleason评分升级具有重要相关性(OR=0.981)。结论通过测量前列腺体积可预测前列腺癌术后病理Gleason评分较穿刺病理Gleason评分升高的可能,从而准确估算前列腺癌患者的实际Gleason评分,以便做出更有利的医疗决策。Objective To explore the correlated factors of the Gleason score upgrading in patients underwent radical prostatectomy after extend prostate biopsy. Methods This retrospective study included a total of 102 patients underwent radical prostatectomy at our institute after prostate biopsies between January2014 and June 2015. Univariate logistic regression analyses and multivariate logistic regression analyses were applied to assess the potential factors. Results Univariate logistic regression analysis showed that these factors were not significantly associated（P〉0.05） with Gleason score upgrading included age, body mass index（BMI）, prostate specific antigen（PSA）, prostate volume, PSA density（PSAD） and digital rectal examination（DRE）, while multivariate logistic regression analysis showed prostate volume associated（OR=0.981） with Gleason score upgrading. Conclusion To measure the volume of prostate is helpful to estimate the risk of Gleason score upgrading and provide preferably medical treatment.

关 键 词：前列腺肿瘤 GLEASON评分 前列腺穿刺 前列腺切除术 LOGISTIC回归 

分 类 号：R737.25[医药卫生—肿瘤]