Efficacy of Different Fluids Preload on Propofol Injection Pain:A Randomized,Controlled,Double-blinded Study  

作　　者：袁世荧 罗天元 刘真 林云 

机构地区：[1]Department of Anesthesiology and Intensive Care Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology [2]Department of Anesthesiology,Affiliated Hospital of Zunyi Medical College [3]Department of Anesthesiology,Peking Union Medical College Hospital

出　　处：《Journal of Huazhong University of Science and Technology(Medical Sciences)》2016年第2期249-253,共5页华中科技大学学报（医学英德文版）

摘　　要：Injection pain of propofol remains a common clinical problem. Previous studies demonstrated that propofol injection pain was alleviated by applying nitroglycerin ointment to the skin of injection site, which inspires us to test whether venous vasodilation induced by fluid preload could alleviate the pain. Different types or volumes of fluid preload were compared. 200 ASA Ⅰ-Ⅱ adult patients were randomly assigned to five groups of 40 each. A 20 G cannula was established on the dorsum or wrist of the hand. When fluid preload given with Plasma-Lyte A 100 m L（P100 group）, 250 m L（P250 group）, 500 m L（P500 group）, 0.9% saline 500 m L（N500 group） or Gelofusine 500 m L（G500 group） was completed within 30 min, respectively, Propofol（0.5 mg/kg, 1%） was injected at a rate of 0.5 m L/s. A blind investigator assessed the pain using a four-point scale. Incidence of pain in P100, P250, and P500 groups was 87.5%, 57.5% and 35%, respectively（P〈0.05）. The median pain intensity score was significantly lower in P500 group than that in P250 and P100 groups（P〈0.05 and P〈0.01, respectively）. Comparison of the effect of different types of solution preload indicated that the highest incidence of pain was in N500 group（62.5%）（N500 vs. P500, P=0.014; N500 vs. G500, P=0.007）. The median pain intensity score in N500 group was higher than that in P500 group（P〈0.05） and G500 group（P〈0.05）. There was no significant difference between P500 and G500 groups. It is suggested that Plasma-Lyte A or Gelofusine preload with 500 m L before propofol injection is effective in alleviating propofol-induced pain.Injection pain of propofol remains a common clinical problem. Previous studies demonstrated that propofol injection pain was alleviated by applying nitroglycerin ointment to the skin of injection site, which inspires us to test whether venous vasodilation induced by fluid preload could alleviate the pain. Different types or volumes of fluid preload were compared. 200 ASA Ⅰ-Ⅱ adult patients were randomly assigned to five groups of 40 each. A 20 G cannula was established on the dorsum or wrist of the hand. When fluid preload given with Plasma-Lyte A 100 m L（P100 group）, 250 m L（P250 group）, 500 m L（P500 group）, 0.9% saline 500 m L（N500 group） or Gelofusine 500 m L（G500 group） was completed within 30 min, respectively, Propofol（0.5 mg/kg, 1%） was injected at a rate of 0.5 m L/s. A blind investigator assessed the pain using a four-point scale. Incidence of pain in P100, P250, and P500 groups was 87.5%, 57.5% and 35%, respectively（P〈0.05）. The median pain intensity score was significantly lower in P500 group than that in P250 and P100 groups（P〈0.05 and P〈0.01, respectively）. Comparison of the effect of different types of solution preload indicated that the highest incidence of pain was in N500 group（62.5%）（N500 vs. P500, P=0.014; N500 vs. G500, P=0.007）. The median pain intensity score in N500 group was higher than that in P500 group（P〈0.05） and G500 group（P〈0.05）. There was no significant difference between P500 and G500 groups. It is suggested that Plasma-Lyte A or Gelofusine preload with 500 m L before propofol injection is effective in alleviating propofol-induced pain.

关 键 词：PROPOFOL injection pain Plasma-Lyte A fluid preload GELOFUSINE 

分 类 号：R614[医药卫生—麻醉学]