宫颈癌的生物治疗  

Biological treatment of cervical cancer

作　　者：王欣茹 原继荣[1] 王德莹[1] 吴美丽[1] 

机构地区：[1]哈尔滨医科大学附属第二医院妇产科,哈尔滨150086

出　　处：《新医学》2016年第4期214-217,共4页Journal of New Medicine

摘　　要：宫颈癌是女性生殖系统中最常见的恶性肿瘤,目前其治疗以手术、放射治疗和化学治疗为主,但是治疗效果未能令人满意。近年来多项研究对其他的治疗方法进行了大量的探索。人乳头瘤病毒(HPV)感染是宫颈癌的主要病因,由HPV导致的恶变主要与癌基因E5、E6、E7相关。抑制E6和E7是一个有前景的生物治疗策略。该文就宫颈癌的免疫治疗、分子靶向治疗、基因治疗等生物治疗进展进行综述。Cervical cancer is the most common malignant tumor of the female reproduction system. At present,clinical therapies of cervical carcinoma mainly include surgery,radiotherapy and chemotherapy. However,clinical efficacy is not satisfactory. Recent investigations have focused upon alternative modalities. Human papilloma virus（ HPV） infection is the major cause of cervical cancer. HPV-induced malignancy is mainly correlated with E5,E6 and E7 oncogenes. Inhibition of E6 and E7 oncogenes is a promising biological strategy for cervical cancer. This article reviews research progress on biological treatment of cervical cancer such as immunotherapy,molecular targeted and gene therapies.

关 键 词：宫颈癌 免疫治疗 分子靶向治疗 基因治疗 

分 类 号：R737.33[医药卫生—肿瘤]