南宁地区育龄妇女HPV感染亚型与宫颈上皮内瘤变关系的研究  

Relationship between subtype of human papillomavirus infection and cervical intraepithelial neoplasia in reproductive women from Nanning

作　　者：许莉莉[1] 莫云[1] 赵仁峰[1] 

机构地区：[1]广西壮族自治区人民医院妇科,南宁530021

出　　处：《新医学》2016年第4期266-268,共3页Journal of New Medicine

基　　金：广西医药卫生自筹经费计划课题(Z2014630)

摘　　要：目的探讨南宁地区育龄妇女人乳头瘤病毒(HPV)亚型与宫颈上皮内瘤变(CIN)的关系。方法应用导流杂交基因芯片技术检测248例育龄妇女HPV亚型感染情况,并分析其与CIN的关系。结果正常或慢性宫颈炎组HPV亚型正常或慢性宫颈炎患者HPV亚型以HPV6(31.6%)、HPV11(21.5%)、HPV44(15.8%)、HPV52(15.8%)为主;CINⅠ患者HPV亚型以HPV52(23.3%)、HPV58(18.6%)、HPV16(11.6%)为主;CINⅡ患者HPV亚型以HPV16(41.4%)、HPV52(21.4%)、HPV58(11.4%)为主;CINⅢ患者HPV亚型以HPV16(45.5%)、HPV52(16.4%)、HPV58(12.3%)为主。正常或慢性宫颈炎组、CINⅠ、CINⅡ及CINⅢ组HPV亚型双重或以上感染率分别为10.5%、11.6%、8.3%、7.3%,各组间HPV亚型双重或以上感染率比较差异均无统计学意义(P均>0.05)。结论南宁地区育龄妇女中,引起CIN的HPV高危亚型主要是16、52、58、18,HPV亚型多重感染并未加重CIN的严重程度。Objective To investigate the relationship between the subtype of human papillomavirus infection（ HPV） and cervical intraepithelial neoplasia（ CIN） in the reproductive women from Nanning. Methods The subtype of HPV in 248 reproductive women was detected by flow-through hybridization and gene chip,and its relationship with CIN was also investigated. Results In the healthy women and those with chronic cervicitis,HPV6（ 31. 6%）,HPV11（ 21. 5%）,HPV44（ 15. 8%） and HPV52（ 15. 8%） were the most common subtypes. HPV52（ 23. 3%）,HPV58（ 18. 6%） and HPV16（ 11. 6%） were the dominant subtypes in the CIN Ⅰ group. The most prevalent subtypes were HPV16（ 41. 4%）,HPV52（ 21. 4%） and HPV58（ 11. 4%） in the CINⅡ group. In the CIN Ⅲ group,HPV16（ 45. 5%）,HPV52（ 16. 4%） and HPV58（ 12. 3%） were the most common subtypes. The infection rate of at least two HPV subtypes were 10. 5%,11. 6%,8. 3% and 7. 3% in the normal or chronic cervicitis,CINⅠ,CINⅡ and CIN Ⅲ groups,respectively. No statistical significance was noted among four groups（ all P 〉0. 05）. Conclusions HPV16,52,58 and 18 subtypes have a high risk of leading to CIN in reproductive women from Nanning. Infection of multiple HPV subtypes does not aggravate the severity of CIN.

关 键 词：宫颈上皮内瘤变 人乳头瘤病毒 育龄妇女 基因芯片 

分 类 号：R737.33[医药卫生—肿瘤]