慢性炎症与恶性肿瘤关系的研究进展  

The research progress of relationship between chronic inflammation and malignant tumor

作　　者：许振起[1] 

机构地区：[1]天津市口腔医院,天津300041

出　　处：《医药前沿》2016年第9期12-13,共2页Journal of Frontiers of Medicine

摘　　要：恶性肿瘤严重影响着人类的健康，其发病机制尚未完全阐明。流行病学调查及分子生物学研究均证实恶性肿瘤和慢性炎症存在着关联。炎症细胞、炎性因子等通过破坏基因组稳定性，诱发基因突变，产生有利于肿瘤生长的微环境，调节肿瘤生长和转移。慢性炎症与肿瘤发生关系的深入阐述为肿瘤治疗提供新的靶点。通过抑制癌前病变患者或肿瘤易感者的慢性炎症，可降低癌症发病和复发风险。Malignant tumor seriously affect human health, and its pathogenesis has not been fully elucidated. Epidemiological investigation and molecular biology studies confirm that malignant tumor associated with chroni;： inflammation exists. Inflammatory cells, inflammatory factors and so on, by destroying the stability of the genome, induce gene mutation, microenvironment for tumor growth, regulate tumor growth and metastasis. Expound the relationship between chronic inflammation and tumorigenesi3, can provide new targets for cancer treatment. Chronic inflammation by inhibiting~ reduces the risk of cancer and recurrence.

关 键 词：慢性炎症 恶性肿瘤 炎性因子 肿瘤治疗 

分 类 号：R730.5[医药卫生—肿瘤]