大脑中动脉闭塞患者软脑膜侧支循环的影响因素  

Influencing factors of leptomeningeal collateral circulation in patients with middle cerebral artery occlusion

作　　者：黄显军[1] 朱武生[2] 徐格林[2] 杨倩[1] 葛良[1] 周志明[1] 

机构地区：[1]皖南医学院弋矶山医院神经内科,芜湖241001 [2]南京军区南京总医院神经内科,210002

出　　处：《国际脑血管病杂志》2016年第3期210-213,共4页International Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金，安徽省高等学校自然科学研究项目(KJ2012B313) Fund programs:National Natural Science Foundation of China，Program of the Natural Science Foundation of the Higher Education Institutions of Anhui Province, China

摘　　要：目的：探讨卒中危险因素对大脑中动脉闭塞患者软脑膜侧支循环形成的影响。方法从南京卒中注册系统中提取自2006年6月至2011年12月期间影像学证实为大脑中动脉闭塞的急性脑梗死患者,收集基线临床资料,通过脑血管造影评估软脑膜侧支循环。结果共纳入137例患者,男性100例,平均年龄（55．26±11．71）岁,65例（47．4%）患者侧支循环良好。单变量分析显示,侧支循环不良组年龄[（57．9±9．5）岁对（52．3±13．2）岁；t =2．866,P =0．005]和高血压的患者构成比（70．8%对52．3%；χ2=4．978,P =0．026）显著高于侧支循环良好组。多变量 logistic 回归分析显示,年龄是影响急性大脑中动脉闭塞患者软脑膜侧支循环形成的独立危险因素（优势比0．965,95%可信区间0．934~0．997；P =0．034）。结论年龄是影响大脑中动脉闭塞患者软脑膜侧支循环形成的独立危险因素。Objective To investigated the effect of the risk factors for stroke on the development of leptomeningeal colateral circulation in patients with middle cerebral artery occlusion. Methods Patients with acute ischemic stroke confirmed as middle cerebral artery occlusion by imaging were extracted from the Nanjing Stroke Registry Program between June 2006 and December 2011. The baseline clinical data were colected. Leptomeningeal colateral circulation was assessed by angiography. Results A total of 137 patients were enroled, including 100 males and 37 females; mean age 55. 26 ± 11. 71 years. The colateral circulation of 65 patients （47. 4% ） was good. Univariate analysis showed that the ages （52. 3 ± 13. 2 years vs. 57. 9 ± 9. 5 years; t = 2. 866, P = 0. 005） and the proportion of hypertension （52. 3% vs. 70. 8% ; χ2 = 4. 978, P =0. 026） in the good colateral circulation group were significantly lower than those in the poor colateral circulation group. Multivariate logistic regression analysis showed that age was an independent risk factor for affecting the leptomeningeal colateral circulation in patients with acute middle cerebral artery occlusion （odds ratio, 0. 965, 95% confidence interval 0. 934-0. 997, P = 0. 034）. Conclusions Age is an independent risk factor for affecting the leptomeningeal colateral circulation in patients with middle cerebral artery occlusion.

关 键 词：卒中 脑缺血 梗死 大脑中动脉 侧支循环 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]