陷窝蛋白在脑缺血后血脑屏障破坏中的作用  

Role of caveolins in the blood-brain barrier disruption after cerebral ischemia

作　　者：王昭君 王刘敏 林颖 刘亚红 

机构地区：[1]南京军区南京总医院神经内科,南京大学医学院附属金陵医院,210002

出　　处：《国际脑血管病杂志》2016年第3期254-258,共5页International Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金(31300900,81471182,81200892,81400332) Fund programs:National Natural Science Foundation of China

摘　　要：陷窝蛋白是陷窝的主要组成蛋白，也是实现其生理功能的重要蛋白。陷窝蛋白表达于平滑肌细胞、内皮细胞和脂肪细胞。陷窝既参与了细胞的脂肪摄取、胞吞和胞饮等基本生理过程，也对细胞的信号转导以及大分子物质的转运和通透起着非常重要的作用。随着对陷窝蛋白的分子构成和生物化学功能研究的深入，越来越多的研究表明陷窝及其主要成分陷窝蛋白在脑血管病的病理生理学过程起着重要作用。文章就陷窝蛋白在脑缺血后血脑屏障破坏中的作用进行了综述。Caveolins are the major component proteins of the caveolae, and they are also the essential proteins to carry out the physiological functions of caveolae. Caveolins are expressed in smooth muscle cels, endothelial cels, and adipocytes. Caveolae are not only involved in the basic physiological processes, such as celular fat intake, endocytosis, and pinocytosis, but also play a very important role in cel signal transduction and transport and permeability of macromolecular substance. With the in-depth research on the molecular structure and biochemical function of caveolins, increasing studies have shown that caveolae and their main component caveolins play an important role in the pathophysiological process of cerebrovascular diseases. This article reviews the roles of caveolins in the blood-brain barrier destruction after cerebral ischemia.

关 键 词：卒中 脑缺血 血脑屏障 脑水肿 细胞质膜微囊蛋白 1 

分 类 号：R743[医药卫生—神经病学与精神病学]