巨噬细胞在颅内动脉瘤中的作用  

Roles of macrophages in intracranial aneurysm

作　　者：荣威林 肖茜[2] 李美华[1] 

机构地区：[1]南昌大学第一附属医院神经外科,330006 [2]南昌大学第一附属医院耳鼻喉科,330006

出　　处：《国际脑血管病杂志》2016年第3期279-283,共5页International Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金，江西省科技计划项目(00041081120919028) Fund programs:National Natural Science Foundation of China，Science and Technology Planning Project of Jiangxi Province of China

摘　　要：炎性反应在颅内动脉瘤形成过程中发挥着关键作用。目前，颅内动脉瘤的病理生理学过程主要考虑是由异常的血流动力学和炎性反应共同引起。已有研究表明，颅内动脉瘤壁中存在的炎性细胞主要是单核巨噬细胞，且可分泌多种效应分子，削弱和破坏血管壁结构。因此，研究不同亚型的巨噬细胞及其效应分子在颅内动脉瘤病理生理学过程中所扮演的角色差异，将为探索颅内动脉瘤的发病机制和有效的靶向治疗提供线索。Inflammation plays a key role in the formation of intracranial aneurysm. At present, the pathophysiological processes of intracranial aneurysms are mainly caused by both hemodynamic abnormalities and inflammation. Studies have shown that the inflammatory cels in the intracranial aneurysm wal are mainly mononuclear macrophages, and can secrete various effector molecules, weakening and destroying the structures of the vessel wal . Therefore, the research of the roles of differences played in different subtypes of macrophages and their effector molecules in the pathophysiological processes of intracranial aneurysms wil provide clues for exploring the pathogenesis of intracranial aneurysms and effective targeted therapy.

关 键 词：颅内动脉瘤 巨噬细胞 炎症 

分 类 号：R743[医药卫生—神经病学与精神病学]