鼻咽癌放疗后舌骨及喉室的运动学变化特征  

Kinematic analysis of hyoid bone and laryngeal displacement in patients with nasopharyngeal carcinoma after radiotherapy

作　　者：吴琼[1] 邓翀[1] 李夷民[1] 郑华[1] 楚可新[1] 廖希一[1] 周雨霏[1] 王丽琛[1] 林勤[1] 

机构地区：[1]厦门大学附属第一医院肿瘤中心放疗科,361001

出　　处：《中华放射医学与防护杂志》2016年第4期288-290,共3页Chinese Journal of Radiological Medicine and Protection

基　　金：本研究接受厦门市科技局项目(3502Z20134004)资助,进行“鼻咽癌放疗后吞咽状况”相关研究,本人与本人家属、其他研究者,未因进行该研究而接受任何不正当的职务或财务利益,在此对研究的独立性和科学性予以保证

摘　　要：目的 利用视频造影吞咽检查（VFSS）分析鼻咽癌患者放疗后舌骨运动学变化特征。方法 本试验为前瞻性临床研究,收集2014年10月至2015年5月在本院初治的25例鼻咽癌患者为研究对象,在放疗前后使用普通X射线模拟机采集吞咽视频,通过视频分析软件进行连续快速截图,对比放疗前后吞咽时间、舌骨移动度及平均移动速度。结果 25例受试者放疗后平均吞咽时间较放疗前延长[（1.38±0.23）s vs.（1.12±0.26）s,t=-9.53,P〈0.05）,舌骨水平方向移动度（HHD） 较放疗前降低［（0.78±0.24）cm vs.（1.01±0.25）cm,t=5.82,P〈0.05）,舌骨垂直方向移动度（HVD） 也较放疗前降低［（0.78±0.18）cm vs.（1.01±0.25）cm,t=2.56,P〈0.05],舌骨平均移动速度放疗后明显降低[（0.83±0.19）cm/s vs.（1.31±0.45）cm/s,t=6.46,P〈0.05]。喉室移动度放疗前后比较,差异无统计学意义（P〉0.05）。结论 鼻咽癌患者放疗后吞咽时间较前延长,舌骨移动度及平均移动速度较前降低。临床试验注册 中国临床试验注册中心,ChiCTR-OOC-16007913。Objective To investigate the swallowing kinematics of the hyoid bone after radiotherapy by video-fluoroscopic swallowing study （VFSS）. Methods This experiment was a prospective clinical study. Between October 2014 and May 2015, a total of 25 eligible patients with nasopharyngeal carcinoma received video-fluoroscopic swallowing exams by X-Ray simulator. All swallowing videos had been fast continuously captured through video analysis software. The duration of deglutition, the displacement and the average velocity of the hyoid bone were analyzed. Results The mean duration of swallowing after treatment was significantly longer [（1.38±0.23）s vs. （1.12±0.26）s, t=-9.53, P〈0.05]. The hyoid horizontal displacement （HHD） after treatment was reduced [（0.78±0.24） cm vs. （1.01±0.25） cm, t=5.82, P〈0.05]. The hyoid vertical displacement （HVD） after treatment was reduced [（0.78±0.18）cm vs. （1.01±0.25）cm, t=2.56, P〈0.05]. The average velocity of the hyoid bone after treatment was also reduced [（0.83±0.19）cm/s vs. （1.31±0.45）cm/s, t=6.46, P〈0.05]. There was no significant difference in the displacement of laryngeal before and after radiotherapy（P〉0.05）. Conclusions The duration of swallowing after radiotherapy of nasopharyngeal carcinoma patients is significantly longer, while the displacements and the average velocity of the hyoid bone are reduced. Trial registration Chinese clinical trial registry, ChiCTR-OOC-16007913.

关 键 词：鼻咽癌 吞咽 舌骨 喉室 不良反应 

分 类 号：R739.63[医药卫生—肿瘤]