肝脏外科的新挑战：联合肝脏分隔和门静脉结扎的二步肝切除术  

New challenge of liver surgery： associating liver partition and portal vein ligation for staged hepatectomy

作　　者：王征[1] 周俭[1] 

机构地区：[1]复旦大学附属中山医院肝外科,上海200032

出　　处：《中华消化外科杂志》2016年第5期428-430,共3页Chinese Journal of Digestive Surgery

基　　金：国家自然科学基金面上项目（81572823）;国家杰出青年科学基金（81225019）;十三五国家科技重大专项（2016ZX10002019）

摘　　要：联合肝脏分隔和门静脉结扎的二步肝切除术（ALPPS）作为一全新的手术方式，为既，主因剩余肝脏体积不足，无法行根治性手术切除的月十癌患者带来了希望。目前，ALPPS已在全世界多个中心开展，许多技术的改良亦见报道。然而，关于ALPPS的诸多争议及疑问，如剩余肝脏体积快速增长的原因、手术安全性及远期预后的担忧，以及与传统手术方式比较的优劣等仍无法做出准确而令人信服的回答。目前全世界范围的多中心协作及临床随饥对照研究是关键。笔者相信ALPPS仍有进一步发展的空间。An innovative approach, named associating liver partition and portal vein ligation for staged hepateetomy （ALPPS） , has made possible a marked increase in future liver remnant （FLR） over a short period of time, and has challenged the concept of unresectability. To date, ALPPS has been employed fur a variety of primary and metastatic liver tumors from many centers across the world. Many technical variations of ALPPS have been described. However, much controversy has surrounded this procedure, and many problems remain to be solved, such as the reasons tier rapid hypertrophy, the technical feasibility, safety and long-term oncologic outcomes, and the result compared with the conventional two-stage hepatectomy. These aspects are needed to be evaluated further in large-scale studies. We believe that the ALPPS procedure will has much room tor further development.

关 键 词：肝肿瘤 联合肝脏分隔和门静脉结扎的二步肝切除术 

分 类 号：R735.7[医药卫生—肿瘤]