联合肝脏分隔和门静脉结扎的二步肝切除术基础研究进展  

Updates on associating liver partition and portal vein ligation for staged hepatectomy

作　　者：刘连新[1] 

机构地区：[1]哈尔滨医科大学附属第一医院肝脏外科肝脾外科教育部重点实验室,150001

出　　处：《中华消化外科杂志》2016年第5期441-443,共3页Chinese Journal of Digestive Surgery

基　　金：国家自然科学基金面上项目（81272705）

摘　　要：联合肝脏分隔技门静脉结扎的二步肝切除术（ALPPS）作为一种新兴手术方式，主要应用于剩余肝脏体积（FLR）不足的晚期肝脏肿瘤患者。ALPPS能够在短期内使FLR迅速增长，从而满足术后上E常的肝脏功能。通过建立ALPPS大鼠模型使肝脏再生的基础研究也取得了一定成果，与肝脏再生有关的信号通路如细胞因子及转导因子的协同作用促进了肝脏的明显再生。The associating liver partition and portal vein ligation for staged hepatectomy （ALPPS） procedure is a new surgieal strategy. ALPPS is mainly used in the patients with insufficient future liver remnant （FLR） and advanced liver tumor. ALPPS provides fast and effective growth of FLR, so as to meet the normal liver function after surgery. The preliminary studies of liver regeneration of ALPPS rat model also have obtained certain achievements, a synergistic activation of the liver regeneration-associated signaling pathways, such as cytokines and transcription factors, contribute to the significant liver regeneration after ALPPS. In this paper, the advantages of ALPPS and preliminary research progress are summarized.

关 键 词：肝肿瘤 联合肝脏分隔及门静脉结扎的二步肝切除术 剩余肝脏体积 肝再生 细胞因子 

分 类 号：R735.7[医药卫生—肿瘤]