中风1号对急性缺血性脑卒中的临床干预及同型半胱氨酸、内皮素的影响  

Stroke One Prescription on Cerebral Arterial Thrombosis and Homocysteine and Endothelin

作　　者：胡万华[1] 陈克龙[1] 张慧和 吴志敏[1] 吴旭杰 赵娜[1] 周荣[1] 

机构地区：[1]温州市中医院神经内科,浙江温州325000

出　　处：《中华中医药学刊》2016年第5期1120-1122,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省中医药科技计划项目(2011-139)

摘　　要：目的:观察中风1号治疗缺血性脑卒中气虚血瘀证患者的疗效及对血浆同型半胱氨酸、内皮素的影响。方法:将200例患者按随机单盲原则分为两组,每组100例,两组在同等西医治疗基础上,治疗组加用中风1号,14天为1个疗程,测定治疗前后神经功能缺损评分(NIHSS)评分、改良Rankin量表(mRS)评分、Barthel指数(BI)评分和血浆同型半胱氨酸、内皮素水平。结果:与对照组相比,治疗14 d后治疗组NIHSS评分及BI评分明显改善(P<0.05);血浆同型半胱氨酸、内皮素水平降低(P<0.05)。治疗组90 d的生活能力明显改善(P<0.05)。结论:中风1号治疗缺血性脑卒中是有效安全的,其机制可能与降低同型半胱氨酸、内皮素水平,减少内皮细胞损伤有关。Objective： To observe the curative effect of Stoke One Prescription on patients with cerebral arterial thrombosis and Qi deficiency and blood stasis,also,the effect on plasma homocysteine and endothelin. Methods： A total of 200 cases were divided into two groups according to single- blind randomizes principle（ 100 cases per group）. On the same bases of western medicine treatment,the treatment group was treated with Stroke One Prescription,with a course of treatment of 14 days. We measured the scores of National Institutes of Health Stroke Scale（ NIHSS）,modified Rankin Scale（ mRS）,Barthel Index（ BI）,as well as plasma homocysteine and endothelin levels before and after treatment. Results：Compared with the control group,the NIHSS and BI scores improved significantly in the treatment group with 14 days treatment（ P〈0. 05）. The levels of plasma homocysteine and endothelin of treatment group were decreased（ P〈0. 05）. The activity of daily living of treatment group was improved dramatically after 90 days treatment（ P〈0. 05）. Conclusion： Stroke One Prescription is safe and effective to be applied to the treatment of cerebral arterial thrombosis,the mechanism of which may be related with the decreased levels of homocysteine,endothelin and the reduced injury of intracutaneous cell.

关 键 词：中风1号 急性 缺血性脑卒中 临床 同型半胱氨酸 内皮素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]