新型含二硫代甲酸酯侧链三氮唑化合物的合成及抗真菌活性研究  

Synthesis and antifungal activities of novel triazole derivatives with dithiocarbamates side chain

作　　者：张治强[1] 付奔 王保刚[1] 张超[2] 廖万清[2] 潘炜华[2] 郭忠武[1] 

机构地区：[1]第二军医大学药学院有机化学教研室,上海200433 [2]第二军医大学长征医院皮肤科,上海200003

出　　处：《药学服务与研究》2016年第2期94-97,共4页Pharmaceutical Care and Research

基　　金：国家自然科学基金(20972188);上海市科学技术委员会重点攻关课题(09dZ1976700;10dZ2220100)

摘　　要：目的:合成含有二硫代甲酸酯侧链的新型三氮唑化合物,并研究其体外抗真菌活性。方法:设计合成了9个新目标化合物,其结构通过1 H-NMR、MS确证,选择8种真菌为实验菌株,测试其体外抑菌活性。结果:所有化合物对所选真菌均表现出了一定的抑菌活性,部分化合物对光滑假丝酵母菌的抑制作用优于对照药氟康唑。结论:引入二硫代甲酸酯侧链的目标化合物都具有一定的抗真菌活性。Objective：To synthesize a series of novel triazole derivatives with dithiocarbamates side chain and evaluate their antifungal activities.Methods：Nine target compounds were synthesized and their structure characterizations were conformed by1 H-NMR and MS spectra.The in vitro antifungal activities of all the compounds were evaluated against eight human pathogenic fungi.Results：Potent antifungal activities were exhibited in all the target compounds,some of which showed potent antifungal activity against Candida glabrata,which was superior to such control drugs as fluconazole.Conclusion：The target compounds with dithiocarbamates side chain have potent antifungal activity.

关 键 词：三唑类衍生物 化学合成 抗真菌活性 

分 类 号：R914.5[医药卫生—药物化学] R962[医药卫生—药学]