幼年型复发性呼吸道乳头状瘤病HPV型别测定和临床分析  

HPV type determination and clinical characteristics in juvenile onset recurrent respiratory papillomatosis

作　　者：杨蓦雷 王军[1] 肖洋[1] 

机构地区：[1]首都医科大学附属北京同仁医院耳鼻咽喉头颈外科,北京100730

出　　处：《临床耳鼻咽喉头颈外科杂志》2016年第9期730-732,736,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：国家自然科学基金资助项目(No:81170900)

摘　　要：目的:探讨人乳头瘤病毒(HPV)感染型别与幼年型复发性呼吸道乳头状瘤病(JORRP)患儿临床特征之间的联系。方法:回顾性分析2010-2014年就诊的240例JORRP患儿,取手术时留取的肿瘤标本进行HPV型别测定,分析感染不同HPV亚型患儿临床表现的差异。结果:JORRP患儿病毒感染型别除单纯HPV11型感染或HPV6型感染外,存在部分HPV11和HPV6型混合感染;感染HPV11型的患儿较感染HPV6型患儿发病年龄小、手术次数多、术中Derkay评分更高,经检验结果差异有统计学意义(P<0.05)。结论:从发病年龄、手术次数及肿瘤生长方式角度考量,感染HPV11型的患儿病情较感染HPV6型的患儿更为严重。Objective：To investigate the relationship between different subtypes of human papillomavirus（HPV）infection and clinical features in juvenile onset recurrent respiratory papillomatosis（JORRP）patients.Method：Two hundred and forty cases with JORRP from 2010 to 2014were retrospectively analyzed.HPV tpye were determined using tumor specimens taken from surgery,and all patients were divided into different groups based on HPV type.Clinical characteristics of patients from each groups were analyzed.Result：Except for HPV11 single infection or HPV6 single infection,some HPV11 and 6co-infections were found in children with JORRP.Compared with patients with HPV6 single infection,HPV11 positive patients present an earlier age of onset,more times of operation and higher derkay score during surgery.Conclusion：JORRP in patients infected with HPV11 is more severe than that in patients with HPV6 infection in children.

关 键 词：人乳头状瘤病毒 呼吸道肿瘤 儿童 

分 类 号：R739.6[医药卫生—肿瘤]