TRPM7与肿瘤  

TRPM7 and tumor

作　　者：赵敏[1,2] 罗晨辉[1,2,3] 王瑛[3] 王静[3] 

机构地区：[1]中南大学湘雅医院临床药理研究所,长沙410008 [2]中南大学临床药理研究所,遗传药理学湖南省重点实验室,长沙410078 [3]湖南省肿瘤医院,长沙410013

出　　处：《中南大学学报（医学版）》2016年第3期333-336,F0003,共5页Journal of Central South University ：Medical Science

基　　金：湖南省自然科学基金(2015JJ2093)~~

摘　　要：瞬时受体电位(transient receptor potential,TRP)通道是位于细胞膜上的一类重要的阳离子通道超家族。TRPM(transient receptor potential melastatin)7是TRPM亚族的一员,是具有离子通道和激酶活性双功能的膜蛋白。它对阳离子有通透性,使细胞去极化,可使自身和底物磷酸化。TRPM7可以介导感觉信号的传递,调节细胞钙镁平衡和影响发育,其表达及活性异常与多种疾病特别是肿瘤的发生具有相关性。TRPM7通道激酶在细胞的增殖、存活、分化、生长和迁移等一系列细胞活动中起重要作用。The transient receptor potential（TRP） family is a superfamily of cation channels located on the cell membrane. Transient receptor potential melastatin（TRPM） 7, a member of the TRPM subgroup of TRP channels, and was the most representative biofunctional membrane protein. It conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. It is capable of phosphorylating TRPM7 and other substrates. TRPM7 can mediate sensory transmission, regulate cellular Ca2＋ and Mg2＋ homeostasis and affect embryonic development. Abnormal expression and/or activity of the TRPM7 channel kinase is involved in a variety of diseases, particularly the development and progression of cancer. TRPM7 channel-kinase is essential for cellular processes, such as proliferation, survival, diff erentiation, growth, and migration.

关 键 词：瞬时受体电位通道 TRPM7 恶性肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]